Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis

Aleksander Obtułowicz; Daryna Barouka; Dominika Kapusta; Norbert Kapczyński; Marta Lato; Andrzej Jaworek; Bartosz Obtułowicz; Anna Wojas-Pelc

doi:10.5114/pja.2025.153695

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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3/2025
vol. 12

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abstract:

Case report

Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis

Aleksander Obtułowicz

¹

,

Daryna Barouka

²

,

Dominika Kapusta

²

,

Norbert Kapczyński

²

,

Marta Lato

¹

,

Andrzej Jaworek

¹

,

Bartosz Obtułowicz

²

,

Anna Wojas-Pelc

¹

Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland
Students’ Dermatology Research Association, Jagiellonian University Medical College, Krakow, Poland

Alergologia Polska – Polish Journal of Allergology 2025; 12, 3: 227–231

DOI: https://doi.org/10.5114/pja.2025.153695

Online publish date: 2025/08/20

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AMA

Obtułowicz A, Barouka D, Kapusta D, et al. Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis. Alergologia Polska - Polish Journal of Allergology. 2025;12(3):227-231. doi:10.5114/pja.2025.153695.

APA

Obtułowicz, A., Barouka, D., Kapusta, D., Kapczyński, N., Lato, M.,  & Jaworek, A. et al. (2025). Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis. Alergologia Polska - Polish Journal of Allergology, 12(3), 227-231. https://doi.org/10.5114/pja.2025.153695

Chicago

Obtułowicz, Aleksander, Daryna Barouka, Dominika Kapusta, Norbert Kapczyński, Marta Lato, Andrzej Jaworek,  and Bartosz Obtułowicz et al. 2025. "Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis". Alergologia Polska - Polish Journal of Allergology 12 (3): 227-231. doi:10.5114/pja.2025.153695.

Harvard

Obtułowicz, A., Barouka, D., Kapusta, D., Kapczyński, N., Lato, M., Jaworek, A., Obtułowicz, B.,  and Wojas-Pelc, A. (2025). Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis. Alergologia Polska - Polish Journal of Allergology, 12(3), pp.227-231. https://doi.org/10.5114/pja.2025.153695

MLA

Obtułowicz, Aleksander et al. "Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis." Alergologia Polska - Polish Journal of Allergology, vol. 12, no. 3, 2025, pp. 227-231. doi:10.5114/pja.2025.153695.

Vancouver

Obtułowicz A, Barouka D, Kapusta D, Kapczyński N, Lato M, Jaworek A et al. Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis. Alergologia Polska - Polish Journal of Allergology. 2025;12(3):227-231. doi:10.5114/pja.2025.153695.

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Tumor necrosis factor-α (TNF-α) inhibitors, such as adalimumab, are widely used for the treatment of various inflammatory diseases, including psoriasis. Injection site reactions (ISRs) are common side effects, typically mild and self-limiting. Nevertheless, in some cases, ISRs may persist or evolve into more severe hypersensitivity reactions, requiring discontinuation or a change of the therapy. We present the case of a 40-year-old woman with plaque psoriasis who developed progressive ISRs and recall reactions during adalimumab therapy. Allergological diagnostics confirmed a delayed-type hypersensitivity reaction. Transitioning to an IL-12/IL-23 inhibitor resulted in clinical improvement, highlighting the importance of allergological testing and alternative biologic therapies.

keywords:

Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis

Aleksander Obtułowicz 1 , Daryna Barouka 2 , Dominika Kapusta 2 , Norbert Kapczyński 2 , Marta Lato 1 , Andrzej Jaworek 1 , Bartosz Obtułowicz 2 , Anna Wojas-Pelc 1

adalimumab, injection site reaction, recall reaction, delayed hypersensitivity, plaque psoriasis

Aleksander Obtułowicz

¹

,

Daryna Barouka

²

,

Dominika Kapusta

²

,

Norbert Kapczyński

²

,

Marta Lato

¹

,

Andrzej Jaworek

¹

,

Bartosz Obtułowicz

²

,

Anna Wojas-Pelc

¹