Abstract
6/2007
vol. 6
MMAC/PTEN gene expression in endometrial cancer – RT-PCR studies
Przegląd Menopauzalny 2007; 6: 344-346
Online publish date: 2007/12/19
Mutations in the MMAC/PTEN (phosphatase and tensin homologue deleted on chromosome 10) gene are documented in cancers of the breast, prostate, ovary, colon, melanoma, glioblastoma, lymphoma and endometrium.
In the present work MMAC/PTEN gene expression in women with endometrial adenocarcinoma (n=70) in RNA samples obtained from cancer tissue were investigated. Control DNA was obtained from 68 normal endometrial tissue samples. The MMAC/PTEN expression was determined by RT-PCR analysis.
Expression of the MMAC/PTEN gene in endometrial adenocarcinoma cases was significantly reduced compared to the expression in the normal samples (p<0.05). Furthermore a significant difference (p<0.05) was observed between the expression of MMAC/PTEN in stage III versus lower stages of endometrial cancer.
The results support the hypothesis that MMAC/PTEN gene expression may be associated with the incidence of endometrial cancer.
In the present work MMAC/PTEN gene expression in women with endometrial adenocarcinoma (n=70) in RNA samples obtained from cancer tissue were investigated. Control DNA was obtained from 68 normal endometrial tissue samples. The MMAC/PTEN expression was determined by RT-PCR analysis.
Expression of the MMAC/PTEN gene in endometrial adenocarcinoma cases was significantly reduced compared to the expression in the normal samples (p<0.05). Furthermore a significant difference (p<0.05) was observed between the expression of MMAC/PTEN in stage III versus lower stages of endometrial cancer.
The results support the hypothesis that MMAC/PTEN gene expression may be associated with the incidence of endometrial cancer.
Keywords
MMAC/PTEN, expression, sporadic endometrial cancer, RT-PCR
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