eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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5/2020
vol. 12
 
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abstract:
Original paper

Endovascular implantation of iodine-125 seed strand combined and stent placement for locally advanced pancreatic ductal adenocarcinoma with vascular invasion: a prospective single-arm pilot study

Linlin Wu
1
,
Yanbo Zhang
2
,
Zihan Zhang
3
,
Fengfeng Li
4
,
Jianjun Luo
3

1.
Department of Oncology, Tengzhou Central People’s Hospital, Tengzhou City, Shandong Province, China
2.
Department of Pharmacy, Tengzhou Central People’s Hospital, Tengzhou City, Shandong Province, China
3.
Department of Interventional Radiology, Affiliated Zhongshan Hospital of Fudan University, Xuhui District, Shanghai, China
4.
Department of Neurosurgery, Tengzhou Central People’s Hospital, Tengzhou City, Shandong Province, China
J Contemp Brachytherapy 2020; 12, 5: 427–434
Online publish date: 2020/10/30
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Introduction
To investigate the safety and feasibility of endovascular brachytherapy using iodine-125 (125I) seed strand for locally advanced pancreatic ductal adenocarcinoma (PDAC) with vascular invasion.

Material and methods
From January 2010 to January 2015, 12 patients diagnosed with locally advanced, inoperable PDAC with splenic or superior mesenteric vein invasion were enrolled in the present study and received endovascular brachytherapy combined with regional intra-arterial infusion chemotherapy. Standardized software was used for dose calculation. Procedure-related and radiation complications were documented and assessed. Overall survival was calculated with the Kaplan-Meier approach.

Results
The technical success rate of 125I seed strand implantation and stent placement was 100%. During follow-up with a mean duration of 17.00 ±6.07 months (range, 6~24 months), the mean and median survival times were 12.0 ±2.4 months (95% CI: 7.4~16.6 months) and 10.7 ±1.4 months (95% CI: 8.0~13.5 months), respectively. One month after the treatment, the disease control and objective rates were 83.8% and 58.3%, respectively. The 6-, 12-, and 15-month cumulative survival rates were 66.7%, 47.6%, and 9.5%, respectively.

Conclusions
Endovascular brachytherapy using 125I seed strand and stent placement may be a safe and effective treatment option for locally advanced pancreatic duct adenocarcinoma with vascular invasion.

keywords:

pancreatic ductal adenocarcinoma, 125I seed strand, vascular invasion

 
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