eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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3/2018
vol. 15
 
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abstract:
Original paper

Evaluation of the metabolic response to open and minimally invasive resection of the oesophagus due to oesophageal cancer

Jarosław Pieróg
,
Michał Bielewicz
,
Janusz Wójcik
,
Bartosz Kubisa
,
Krzysztof Kaseja
,
Krzysztof Safranow
,
Magdalena Dołęgowska
,
Piotr Waloszczyk
,
Tomasz Grodzki

Kardiochirurgia i Torakochirurgia Polska 2018; 15 (3): 151-156
Online publish date: 2018/09/24
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Aim
The aim of this study was to compare the metabolic response in the early postoperative period after radical resection of stage I and II oesophageal cancer applying a minimally invasive procedure and an open procedure involving classical laparotomy and thoracotomy.

Material and methods
Serum concentrations of interleukin 6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor- (TNF-), and total serum protein (TP) and leukocyte count (WBC) in blood collected on the day of surgery prior to the procedure (day 0) and on days 1, 2 and 7 after the surgery were measured in two groups of patients undergoing oesophageal resection due to cancer: applying a minimally invasive procedure involving laparoscopy and videothoracoscopy (group A) and applying a classical procedure involving full opening of the chest and abdominal cavity (group B). The study involved a total of 24 patients divided into two groups of 12 patients each.

Results
Tumour necrosis factor- concentration was lower in group A compared to group B on day 0, PCT concentration was lower in group A compared to group B on day 2 after surgery, and on the remaining days TNF- and PCT concentrations were not statistically different between groups.

Conclusions
Lower concentration of PCT on post-surgery day 2 in the group of patients undergoing minimally invasive oesophageal resection seems to be associated with a smaller perioperative injury. Lower TNF- concentration in serum collected on day 0 in the group of patients undergoing minimally invasive resection is associated with a lower stage of oesophageal cancer in this group.

keywords:

minimally invasive resection of oesophagus, oeso-phageal cancer, metabolic response

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