eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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5/2020
vol. 12
 
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abstract:
Original paper

Feasibility and early toxicity of focal or partial brachytherapy in prostate cancer patients

Tae Heon Kim
1
,
Jong Nyeong Kim
1
,
Young Dong Yu
1
,
Seung Ryeol Lee
1
,
Young Kwon Hong
1
,
Hyun Soo Shin
2
,
Dong Soo Park
1

1.
Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
2.
Department of Radiation Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
J Contemp Brachytherapy 2020; 12, 5: 420–426
Online publish date: 2020/10/30
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Introduction
The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients.

Material and methods
Medical records of eligible patients who underwent focal/partial LDR-BT and whole LDR-BT between 2015 and 2017 at our institution were reviewed retrospectively. Clinical characteristics and pathologic outcomes were compared between focal/partial LDR-BT group and whole LDR-BT group. Biochemical recurrence-free survival was analyzed using Kaplan-Meier method and difference between two groups was assessed with log-rank test. Genitourinary and rectal toxicity were also evaluated between the two groups.

Results
Of the 60 patients analyzed, 30 focal/partial LDR-BT patients and 30 whole LDR-BT brachytherapy patients were included. Relative to the whole LDR-BT group, the focal/partial LDR-BT group had significantly higher initial PSA level (p = 0.002), smaller number of implanted seeds (p < 0.001), and shorter follow-up duration (p < 0.001). There was no significant difference between the two groups with regard to prostate volume, biopsy Gleason score, and risk group stratification. The 3-year biochemical recurrence-free survival estimates for focal/partial LDR-BT group and whole LDR-BT group were 91.8% and 89.6%, respectively, which was not significantly different (p = 0.554). Genitourinary symptoms were significantly worse in whole LDR-BT group than in focal/partial LDR-BT group. The incidence of rectal toxicity was similar between two groups.

Conclusions
Our findings indicate that the focal/partial LDR-BT is comparable to the whole LDR-BT with respect to short-term biochemical recurrence and toxicities.

keywords:

prostate cancer, brachytherapy, focal therapy, biochemical recurrence, toxicity

 
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