Journal of Contemporary Brachytherapy

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma

Adam Deja 1
,
Patrycja Pijanka-Maciaszczyk 2
,
Piotr Milecki 1
,
Iwona Rospond-Kubiak 2

  1. Radiotherapy Department, The Greater Poland Cancer Centre, Poznan, Poland

  2. Department of Ophthalmology, Poznan University of Medical Sciences, Poznan, Poland


J Contemp Brachytherapy 2026; 18



DOI: https://doi.org/10.5114/jcb.2026.161861
Data publikacji online: 2026/05/26
Article file
Fractionated stereotactic.pdf
  1. Krantz BA, Dave N, Komatsubara KM et al. Uveal melanoma: epidemiology, etiology, and treatment of primary disease. Clin Ophthalmol 2017; 11: 279-289.
  2. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors (COMS report No. 28). Arch Ophthalmol 2006; 124: 1684-1693.
  3. Collaborative Ocular Melanoma Study Group. Visual acuity after iodine-125 plaque radiotherapy for medium choroidal melanoma: COMS report No. 16. Ophthalmology 2001; 108: 348-366.
  4. Diener-West M, Earle JD, Fine SL et al. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. Arch Ophthalmol 2001; 119: 969-982.
  5. Fionda B, Pagliara MM, Chyrek AJ et al. Ocular brachytherapy (interventional radiotherapy): preserving the vision. Clin Oncol 2023; 35: e445-e452.
  6. Collaborative Ocular Melanoma Study Group. Incidence of cataract and outcomes after cataract surgery in the first 5 years after iodine 125 brachytherapy: COMS Report No. 27. Ophthalmology 2007; 114: 1363-1371.
  7. Karimi S, Arabi A, Siavashpour Z et al. Efficacy and complications of ruthenium-106 brachytherapy for uveal melanoma: a systematic review and meta-analysis. J Contemp Brachytherapy 2021; 13: 358-364.
  8. Buonanno F, Conson M, de Almeida Ribeiro C et al. Local tumor control and treatment-related toxicity after plaque brachytherapy for uveal melanoma: a systematic review and pooled analysis. Radiother Oncol 2022; 166: 15-25.
  9. Summanen P, Immonen I, Kivelä T et al. Radiation-related complications after ruthenium plaque radiotherapy of uveal melanoma. Br J Ophthalmol 1996; 80: 732-739.
  10. Rospond-Kubiak I, Wróblewska-Zierhoffer M, Twardosz-Pawlik H et al. Ruthenium brachytherapy for uveal melanoma – single institution experience. J Contemp Brachytherapy 2017; 9: 548-552.
  11. Peddada KV, Sangani R, Menon H et al. Complications and adverse events of plaque brachytherapy for ocular melanoma. J Contemp Brachytherapy 2019; 11: 392-397.
  12. Puusaari I, Heikkonen J, Kivela T. Ocular complications after iodine brachytherapy for large uveal melanomas. Ophthalmology 2004; 111: 1768-1777.
  13. Shields CL, Shields JA, Cater J et al. Transpupillary thermotherapy for choroidal melanoma: tumor control and visual results in 100 consecutive cases. Ophthalmology 1998; 105: 581-590.
  14. Damato B, Groenewald C, McGalliard J et al. Primary transpupillary thermotherapy for choroidal melanoma: preliminary results. Br J Ophthalmol 1996; 80: 1092-1098.
  15. van Beek JGM, Ramdas WD, Angi M et al. Local tumour control and radiation side effects for fractionated stereotactic photon beam radiotherapy compared to proton beam radiotherapy in uveal melanoma. Radiother Oncol 2021; 157: 219-224.
  16. Archer DB, Amoaku WM, Gardiner TA. Radiation retinopathy – clinical, histopathological, ultrastructural and experimental correlations. Eye 1991; 5: 239-251.
  17. Kaliki S, Shields CL, Rojanaporn D et al. Scleral necrosis after plaque radiotherapy of uveal melanoma: a case-control study. Ophthalmology 2013; 120: 1004-1011.
  18. Kim EA, Salazar D, McCannel CA et al. Glaucoma after iodine-125 brachytherapy for uveal melanoma: incidence and risk factors. J Glaucoma 2020; 29: 1-10.
  19. Groenewald C, Konstantinidis L, Damato B. Effects of radiotherapy on uveal melanomas and adjacent tissues. Eye 2013; 27: 163-171.
  20. Tran K, Schefler AC, Chevli N et al. Re-treatment of locally recurrent uveal melanoma with repeat eye plaque I-125 brachytherapy: A single institution experience. Brachytherapy 2024; 23: 604-609.
  21. King B, Morales-Tirado VM, Wynn HG et al. Repeat episcleral plaque brachytherapy: clinical outcomes in patients treated for locally recurrent posterior uveal melanoma. Am J Ophthalmol 2017; 176: 40-45.
  22. Riechardt AI, Cordini D, Dobner B et al. Salvage proton beam therapy in local recurrent uveal melanoma. Am J Ophthalmol 2014; 158: 948-956.
  23. Sorour OA, Mignano JE, Duker JS et al. Gamma Knife radiosurgery for locally recurrent choroidal melanoma following plaque radiotherapy. Int J Retin Vitr 2018; 4: 23.
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