Przegląd Menopauzalny

Abstract

3/2013 vol. 12
Review paper

TP53 gene and p53 protein vs. endometrial carcinoma

Agnieszka Zając
,
Grzegorz Stachowiak
,
Tomasz Stetkiewicz
,
Jacek R. Wilczyński
Przegląd Menopauzalny 2013; 17 (3): 228–230
DOI: https://doi.org/10.5114/pm.2013.36588
Online publish date: 2013/07/25
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Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
The TP53 gene and its protein p53 play an important role in the cell cycle, DNA repair and apoptosis initiation. Genetic anomalies of TP53 are related to some neoplasms, including endometrial cancer. These alterations may initiate cancerogenesis within endometrium, being observed in type II and poorly-differentiated carcinomas. Immunoexpression of TP53/p53 may be helpful in the diagnostic and therapeutic process and be a prognostic factor for this carcinoma.

Keywords

endometrial carcinoma, TP53, p53, menopause

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