eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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4/2019
vol. 11
 
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abstract:
Original paper

Hypofractionated 192Ir source stereotactic ablative brachytherapy with coplanar template assistance in the primary treatment of peripheral lung cancer

Haowen Pang
,
Kui Wu
,
Xiangxiang Shi
,
Tao Tang
,
Xiaoyang Sun
,
Bo Yang
,
Jingbo Wu
,
Sheng Lin

J Contemp Brachytherapy 2019; 11, 4: 370–378
Online publish date: 2019/08/22
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Purpose
In this study, we reported the safety and efficacy of hypofractionated 192Ir source stereotactic ablative brachytherapy (SABT) with coplanar template assistance for peripheral lung cancer, and compared the dosimetric parameters between SABT and stereotactic body radiotherapy (SBRT).

Material and methods
Thirty-three peripheral lung cancer patients, with the gross lung tumor volume (GTVL) < 5 cm in diameter were enrolled in this study. We assessed the safety and efficacy of SABT, and compared the dosimetric parameters between SABT and SBRT.

Results
Chest computed tomography (CT) of post-SABT revealed mild pneumothorax in 2 of 33 patients. Complete response (CR) plus partial response (PR) rate for GTVL at 6-month was 100%. Local control (LC) rate for GTVL at 1-year was 96.9%. For organs at risk (OARs), D1000 cm3, and D1500 cm3 for lung in 1, 3, and 5 fractions were not statistically different between SABT and SBRT (all p > 0.05); the remaining dosimetric parameters were significantly lower in SABT than in SBRT (all p < 0.01).

Conclusions
SABT can provide safe and effective treatment, and warrant generalization for peripheral lung cancer.

keywords:

192Ir source, brachytherapy, coplanar template, peripheral lung cancer

 
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