Alergologia Polska - Polish Journal of Allergology

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2/2026 vol. 13
Case report

Is facial swelling always an allergy? A case of superior vena cava syndrome mimicking angioedema

  1. Department of Internal Medicine, Independent Public Specialist John Paul II Western Hospital, Grodzisk Mazowiecki, Poland
  2. Department of Internal Diseases, Infectious Diseases, and Allergology, Military Institute of Medicine – National Research Institute, Warsaw, Poland

Alergologia Polska – Polish Journal of Allergology 2026; 13, 2: 166–171


Data publikacji online: 2026/04/24
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  1. Quencer KB. Superior vena cava syndrome: etiologies, manifestations, and treatments. Semin Interv Radiol 2022; 39: 292-303.
  2. Harvey JJ, Vrazas JI, Bekhit E, et al. Catheter-related superior vena cava syndrome: an increasing problem. Med J Aust 2024; 220: 238-40.
  3. Wilson LD, Detterbeck FC, Yahalom J. Clinical practice. Superior vena cava syndrome with malignant causes. N Engl J Med 2007; 356: 1862-9.
  4. Azizi AH, Shafi I, Shah N, et al. Superior vena cava syndrome. JACC Cardiovasc Interv 2020; 13: 2896-910.
  5. Cohen R, Mena D, Carbajal-Mendoza R, et al. Superior vena cava syndrome: a medical emergency? Int J Angiol 2008; 17: 43-6.
  6. Shah RP, Bolaji O, Duhan S, et al. Superior vena cava syndrome: an umbrella review. Cureus 2023; 15: e42227.
  7. Yu JB, Wilson LD, Detterbeck FC. Superior vena cava syndrome: a proposed classification system and algorithm for management. J Thorac Oncol 2008; 3: 811-4.
  8. Wong D, Waserman S, Sussman GL. Endotypes of chronic spontaneous urticaria and angioedema. J Allergy Clin Immunol 2025; 156: 17-23.
  9. Bassiouni M, Olze H, Dommerich S. Superior vena cava syndrome with laryngeal edema mimicking drug-induced angioedema: implications for otolaryngology. Ear Nose Throat J 2021; 100: NP379-80.
  10. Johnson JS, Kotora JG, Bechtel BF. Superior vena cava syndrome masquerading as an allergic reaction. Am J Emerg Med 2012; 30: 2100.e1-3..
  11. Salama ME, Ukwade P, Khan AR, Qayyum H. Facial swelling mimicking anaphylaxis: a case of superior vena cava syndrome in the Emergency Department. Cureus 2022; 14: e29678.
  12. Pająk-Grot M, Kozłowska-Murawska J, Siwicka M. Superior vena cava syndrome resembling recurrent Quincke’s oedema. Case report. Dermatol Rev 2011; 98: 266-72.
  13. Mardock P, Eisenberg AP, Shah V, Golden T. Superior vena cava syndrome masquerading as angioedema: a chemotherapy port complication. Cureus 2024; 16: e67329.
  14. Kelbel T, Kuipers C. All that swells is not angioedema: misdiagnosis of superior vena cava syndrome as angioedema. Ann Allergy Asthma Immunol 2023; 131: S128.
  15. Porębski G, Kucharczyk A, Matuszewski T, et al. Position statement of the hereditary angioedema Section of the Polish Society of Allergology on the management of hereditary angioedema due to C1 inhibitor deficiency: 2025 update. Part I: Classification, pathophysiology, clinical presentation, diagnosis, and differential diagnosis. Pol J Allergol 2025; 12: 153-62.
  16. Mansi M, Zanichelli A, Coerezza A, et al. Presentation, diagnosis and treatment of angioedema without wheals: a retrospective analysis of a cohort of 1058 patients. J Intern Med 2015; 277: 585-93.
  17. Sinnathamby ES, Issa PP, Roberts L, et al. Hereditary angioedema: diagnosis, clinical implications, and pathophysiology. Adv Ther 2023; 40: 814-27.
  18. Karadakhy KA, Kakamad FH, Mohammed SH, et al. Recurrent spontaneous subcutaneous emphysema of unknown origin: a case report with literature review. Ann Med Surg 2022; 76: 103443.
  19. Fitzgerald M, Urriola N. Images in allergy subcutaneous emphysema presenting as bilateral periorbital angioedema. J Allergy Clin Immunol Pract 2024; 12: 764-5.
  20. Hammoud R, Emam F, Mohamed S, Abdulkarim H. Acute upper airway obstruction due to massive cervical subcutaneous emphysema: a case report. Cureus 2023; 15: e34420.
  21. Andersen MF, Longhurst HJ, Rasmussen ER, Bygum A. How not to be misled by disorders mimicking angioedema: a review of pseudoangioedema. Int Arch Allergy Immunol 2016; 169: 163-70.
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