Alergologia Polska - Polish Journal of Allergology
eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
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Case report

Local anaesthesia systemic toxicity (LAST) in a pregnant woman following lignocaine administration

Joanna Glück
1
,
Olga Branicka
1
,
Radosław Gawlik
1

  1. Department of Internal Disease, Allergology, and Clinical Immunology, Medical University of Silesia, Katowice, Poland
Alergologia Polska – Polish Journal of Allergology
Online publish date: 2026/05/13
Article file
- Local anaesthesia.pdf  [0.21 MB]
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1. NYSORA. Local anesthetic systemic toxicity. (2023) https://www.nysora.com/topics/complications/local-anesthetic-systemic-toxicity/
2. Long B, Chavez S, Gottlieb M, et al. Local anesthetic systemic toxicity: a narrative review for emergency clinicians. Am J Emerg Med 2022; 59: 42-8.
3. Bern S, Weinberg G. Local anesthetic toxicity and lipid resuscitation in pregnancy. Curr Opin Anaesthesiol 2011; 24: 262-7.
4. Mulroy MF. Systemic toxicity and cardiotoxicity from local anesthetics: incidence and preventive measures. Reg Anesth Pain Med 2002; 27: 556-61.
5. Mulroy MF, Hejtmanek MR. Prevention of local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35: 177-80.
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10. Mock ND, Griggs KM, Mileto LA. Local anesthetic systemic toxicity during labor, birth, and immediate postpartum: clinical review. MCN Am J Matern Child Nurs 2021; 46: 330-8.
11. Macfarlane AJ, Gitman M, Bornstein KJ, et al. Updates in our understanding of local anaesthetic systemic toxicity: a narrative review. Anaesthesia 2021; 76: 27-39.
12. De Valle MK, Adkison M, Maredia R, et al. Local anesthetic systemic toxicity in pregnancy: a retrospective cohort Analysis Cureus 2024; 16: 69215.
13. Bern S, Weinberg G. Local anesthetic toxicity and lipid resuscitation in pregnancy. Curr Opin Anaesthesiol 2011; 24: 262-7.
14. Tsuji M, Nii M, Furuta M, et al. Japan Resuscitation Council (JRC) of the Guideline Editorial Committee. Intravenous lipid emulsion for local anaesthetic systemic toxicity in pregnant women: a scoping review. BMC Pregnancy Childbirth 2024; 14: 138.
15. Di Gregorio G, Neal JM, Rosenquist RW, et al. Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Reg Anesth Pain Med. 2010; 35: 181-7.
16. Gabrieli A, Barberi C, Compostella C, et al. Local anesthetic systemic toxicity joint management in the prehospital environment: a case report. Air Med J 2024; 43: 256-8.
Copyright: © Polish Society of Allergology This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.



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