Modern brachytherapy modalities vs. external beam radiotherapy in post-operative non-melanoma skin cancer: A systematic review
Department of Radiation Oncology, Murni Teguh Memorial Hospital, Indonesia
J Contemp Brachytherapy 2026
Data publikacji online: 2026/09/22
- Apalla Z, Nashan D, Weller RB, Castellsagué X. Skin cancer: epidemiology, disease burden, pathophysiology, diagnosis, and therapeutic approaches. Dermatol Ther (Heidelb) 2017; 7 (S1): 5-19.
- Benkhaled S, Van Gestel D, Gomes da Silveira Cauduro C et al. The state of the art of radiotherapy for non-melanoma skin cancer: a review of the literature. Front Med 2022; 9: 913269.
- Griffin LL, Ali FR, Lear JT. Non-melanoma skin cancer. Clin Med (Northfield Il) 2016; 16: 62-65.
- Raza MW, Prakash S, Singh A et al. Surface mould brachytherapy in superficial tumors, case series from a tertiary cancer centre in North India with review of literature. Asian Pacific J Cancer Biol 2025; 10: 535-539.
- Liu Q, Sha M, Xue B et al. Health-related quality of life and associated factors among non-melanoma skin cancer patients: a cross-sectional study. Ann Transl Med 2023; 11: 150.
- Kalaghchi B, Esmati E, Ghalehtaki R et al. High-dose-rate brachytherapy in treatment of non-melanoma skin cancer of head and neck region: preliminary results of a prospective single institution study. J Contemp Brachytherapy 2018; 10: 115-122.
- Yosefof E, Kurman N, Yaniv D. The role of radiation therapy in the treatment of non-melanoma skin cancer. Cancers (Basel) 2023; 15: 2408.
- Sen S, Bandyopadhyay A, Pal J et al. A dosimetric study of electron beam therapy vs. high-dose-rate mould brachytherapy in adjuvant treatment of non-melanoma skin carcinomas of the head and neck region. J Contemp Brachytherapy 2019; 11: 547-553.
- Renard S, Parent L, de Marzi L et al. Electron radiation therapy: Back to the future? Cancer/Radiothérapie 2024; 28: 553-559.
- Valve A, Koskenmies S, Tenhunen M et al. Early clinical experience with a degraded 4 MeV electron beam in radiotherapy of superficial basal cell carcinoma. Phys Imaging Radiat Oncol 2023; 27: 100487.
- Valve A, Kulmala A, Followill D, Tenhunen M. Modification of the 4 MeV electron beam from a linear accelerator for irradiation of small superficial skin tumors. Phys Imaging Radiat Oncol 2019; 10: 25-28.
- Noshadi S, Atarod M, Amouheidari A et al. Evaluation of therapeutic properties of a low energy electron beam plus spoiler for local treatment of mycosis fungoides: A Monte Carlo study. J Biomed Phys Eng 2020; 10: 441-448.
- Yadavalli P, Pareek V, Barthwal M et al. Clinical and toxicity outcomes with 3D based-HDR surface mold brachytherapy in skin cancer. J Cancer Res Ther 2024; 20: 930-934.
- Szlag M, Wojcieszek P, Kellas-Ślęczka S et al. Individual multi-catheter mould technique in high-dose-rate brachytherapy – personalized approach in treating multifocal angiosarcoma of the face. J Contemp Brachytherapy 2019; 11: 337-342.
- Zwierzchowski G, Bielęda G, Szymbor A, Boehlke M. Personalized superficial HDR brachytherapy – dosimetric verification of dose distribution with lead shielding of critical organs in the head and neck region. J Pers Med 2022; 12: 1432.
- Budrukkar A, Dasgupta A, Pandit P et al. Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region. J Contemp Brachytherapy 2017; 9: 242-250.
- Delishaj D, Rembielak A, Manfredi B et al. Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature. J Contemp Brachytherapy 2016; 8: 533-540.
- Poltorak M, Banatkiewicz P, Poltorak L et al. Brachytherapy and 3D printing for skin cancer: A review paper. J Contemp Brachytherapy 2024; 16: 156-169.
- Licher J, Achenbach J, Köhn J et al. Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer. Strahlenther Onkol 2025; 201: 940-952.
- Fionda B, Placidi E, Rosa E et al. Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer. J Contemp Brachytherapy 2023; 15: 220-223.
- Gogineni E, Cai H, Carillo D et al. Computed tomography-based flap brachytherapy for non-melanoma skin cancers of the face. J Contemp Brachytherapy 2021; 13: 51-58.
- Bandyopadhyay A, Ghosh A, Basu P et al. Computed tomography-based customized surface mould high-dose-rate brachytherapy for non-melanoma skin cancer of the scalp and face. Long-term results: Optimizing for reduction of late toxicity and improving cosmetic outcome. J Contemp Brachytherapy 2026; 18: 58-66.
- Brovchuk S, Park SJ, Shepil Z et al. High-dose-rate skin brachytherapy with interstitial, surface, or a combination of interstitial and surface mold technique. J Contemp Brachytherapy 2022; 14: 107-114.
- Budrukkar A, Singh M, Swain M et al. Interstitial brachytherapy for periocular nonmelanoma skin cancers: Impact on organ and function preservation. Tech Innov Patient Support Radiat Oncol 2024; 32: 100280.
- Casey S, Awotwi-Pratt J, Bahl G. Surface mould brachytherapy for skin cancers: The British Columbia cancer experience. Cureus 2019; 11: e6412.
- Chatzikonstantinou G, Diefenhardt M, Fleischmann M et al. Customized 3D-printed molds for high dose-rate brachytherapy in facial skin cancer: First clinical experience. J Ger Soc Dermatology 2023; 21: 35-41.
- Cisek P, Kieszko D, Bilski M et al. Interstitial HDR brachytherapy in the treatment of non-melanocytic skin cancers around the eye. Cancers (Basel) 2021; 13: 1425..
- Diefenhardt M, Chatzikonstantinou G, Meissner M et al. HDR brachytherapy with individual epithetic molds for facial skin cancer: techniques and first clinical experience. Int J Dermatol 2021; 60: 717-723.
- Esmati E, Abyaneh R, Jaberi R et al. Surface mold brachytherapy for head and neck non-melanoma skin cancer – local control rates and survival: A retrospective analysis. J Contemp Brachytherapy 2024; 16: 323-334.
- Haseltine JM, Parker M, Wernicke AG et al. Clinical comparison of brachytherapy versus hypofractionated external beam radiation versus standard fractionation external beam radiation for non-melanomatous skin cancers. J Contemp Brachytherapy 2016; 8: 189-194.
- Hommadi M, Bakkali H, Houessou O et al. Post-operative high dose rate surface brachytherapy for skin cancer with flap applicator. World J Pharm Med Res 2021; 7: 11-17.
- Krengli M, Masini L, Comoli AM et al. Interstitial brachytherapy for eyelid carcinoma. Outcome analysis in 60 patients. Strahlenther Onkol 2014; 190: 245-249.
- Kuo AM, Lee EH, Rossi AM et al. A multicenter prospective trial of electronic skin surface brachytherapy for keratinocyte carcinoma: early cosmesis, quality of life, and adverse events. Int J Radiat Oncol 2023; 116: 544-550.
- Monge-Cadet J, Vairel B, Morisseau M et al. High-dose-rate brachytherapy for treatment of facial skin cancers: local control, toxicity, and quality of life in 67 patients. Cancers (Basel) 2024; 16: 2742.
- Placidi E, Fionda B, Rosa E et al. Retrospective dosimetric comparison of HDR interventional radiotherapy (brachytherapy) versus planning with VMAT and electron beam therapy for non-melanoma skin cancer treatment. Appl Sci 2024; 14: 10669.
- Poltorak M, Banatkiewicz P, Poltorak L et al. Individualized 3D printing for skin cancer brachytherapy: Development, implementation, clinical applications, and treatment assessment. J Contemp Brachytherapy 2024; 16: 173-183.
- Prasiko G, Acharya B, Karn A et al. Surface brachytherapy in skin cancer with high dose rate remote after loader: an experience from NCHRC. Nepal J Cancer 2020; 4: 94-97.
- Rio E, Bardet E, Ferron C et al. Interstitial brachytherapy of periorificial skin carcinomas of the face: A retrospective study of 97 cases. Int J Radiat Oncol 2005; 63: 753-757.
- Vyas S, Palaniswaamy G, Massingill B et al. Electrons versus surface brachytherapy for non-melanoma skin cancer – a matched pair analysis. Int J Radiat Oncol 2014; 90: S118.
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