Abstract
3/2011
vol. 8
NIEWYDOLNOŚĆ SERCA I PŁUC, TRANSPLANTOLOGIA
Dynamics of the troponin I levels in the first days
after heart transplantation (HTX) in the own material
– a pilot study
Kardiochirurgia i Torakochirurgia Polska 2011; 8 (3): 379–382
Online publish date: 2011/09/30
Background : Troponin is a valuable and highly used marker for the assessment of the myocardial damage. Elevated troponin levels are the result of myocardial injury irrespective of etiology.
Aim : Evaluation of dynamics of troponin I changes in the first days (since “0” to 3rd day) after heart transplantation (HTX).
Material and methods : Retrospective analysis of 42 patients aged 21 to 62 years, average age 47.4 ±12.4. Study group consisted of the
patients which hearts were harvested by two surgeons according to the identical protection scheme using CELSIOR cardioplegic solution. In all patients troponin I levels in the following days after HTX were measured.
Dynamics of troponin I changes was assessed, using the one-step immunoenzymatic test (normal values to 0.1 ng/ml) in all of the patients in the first days after HTX. The highest daily value was taken into the analysis.
Results : Average troponin I levels in the subsequent days after HTX were as follows: 21.7 ±22.1; 21.3 ±22.5; 17.6 ±20.3; 13.2 ±15.3 ng/ml. Based on ANOWA (Kruskal-Wallisa) test statistically significant troponin I levels decrease in the consecutive days after HTX (p = 0.0002) was noted. The biggest decrease was observed between days “0” and “3” and between days “1” and “3” (respectively: 54.1 and 53.7%); the smallest decreased appeared between days “0” and “1” after HTX (0.7%).
Conclusion : Immediately after HTX significantly elevated troponin I levels can be observed that could be connected with perioperative myocardial injury caused by the heart harvesting and transplantation.
Aim : Evaluation of dynamics of troponin I changes in the first days (since “0” to 3rd day) after heart transplantation (HTX).
Material and methods : Retrospective analysis of 42 patients aged 21 to 62 years, average age 47.4 ±12.4. Study group consisted of the
patients which hearts were harvested by two surgeons according to the identical protection scheme using CELSIOR cardioplegic solution. In all patients troponin I levels in the following days after HTX were measured.
Dynamics of troponin I changes was assessed, using the one-step immunoenzymatic test (normal values to 0.1 ng/ml) in all of the patients in the first days after HTX. The highest daily value was taken into the analysis.
Results : Average troponin I levels in the subsequent days after HTX were as follows: 21.7 ±22.1; 21.3 ±22.5; 17.6 ±20.3; 13.2 ±15.3 ng/ml. Based on ANOWA (Kruskal-Wallisa) test statistically significant troponin I levels decrease in the consecutive days after HTX (p = 0.0002) was noted. The biggest decrease was observed between days “0” and “3” and between days “1” and “3” (respectively: 54.1 and 53.7%); the smallest decreased appeared between days “0” and “1” after HTX (0.7%).
Conclusion : Immediately after HTX significantly elevated troponin I levels can be observed that could be connected with perioperative myocardial injury caused by the heart harvesting and transplantation.
Keywords
heart transplantation, troponin, donor’s heart
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