eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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vol. 7

Original paper
Efficacy and safety of electronic brachytherapy for superficial and nodular basal cell carcinoma

Rosa Ballester-Sánchez
Olga Pons-Llanas
Cristian Candela-Juan
Francisco Javier Celada-Alvarez
Blanca de Unamuno-Bustos
Margarita Llavador-Ros
Antonio Ballesta-Cuñat
Christopher A. Barker
Alejandro Tormo-Micó
Rafael Botella-Estrada
Jose Perez-Calatayud

J Contemp Brachytherapy 2015; 7, 3: 231-238
Online publish date: 2015/06/09
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Purpose: Surface electronic brachytherapy (EBT) is an alternative radiotherapy solution to external beam electron radiotherapy and high-dose-rate radionuclide-based brachytherapy. In fact, it is also an alternative solution to surgery for a subgroup of patients. The objective of this work is to confirm the clinical efficacy, toxicity and cosmesis of a new EBT system, namely Esteya® in the treatment of nodular and superficial basal cell carcinoma (BCC).

Material and methods: This is a prospective single-center, non-randomized pilot study to assess the efficacy and safety of EBT in nodular and superficial BCC using the Esteya® system. The study was conducted from June 2014 to February 2015. The follow up time was 6 months for all cases.

Results: Twenty patients with 23 lesions were included. A complete response was documented in all lesions (100%). A low level of toxicity was observed after the 4th fraction in all cases. Erythema was the most frequent adverse event. Cosmesis was excellent, with more than 60% of cases without skin alteration and with subtle changes in the rest.

Conclusions: Electronic brachytherapy with Esteya® appears to be an effective, simple, safe, and comfortable treatment for nodular and superficial BCC associated with excellent cosmesis. It could be a good choice for elderly patients, patients with contraindications for surgery (due to comorbidities or anticoagulant drugs) or patients where surgery would result in a more disfiguring outcome. A longer follow-up and more studies are needed to confirm these preliminary results.

basal cell carcinoma, electronic brachytherapy, skin brachytherapy, skin cancer

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