Abstract
1/2011
vol. 10
Original paper
The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination (XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland
Przegląd Menopauzalny 2011; 1: 10–14
Online publish date: 2011/03/16
Background : Single nucleotide polymorphisms in the DNA repair genes have been extensively studied in association with various human cancers such as breast cancer.
Material and methods : We investigated an association of polymorphisms in the DNA repair genes
XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls.
Results : The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04).
Conclusion : G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women.
Material and methods : We investigated an association of polymorphisms in the DNA repair genes
XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls.
Results : The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04).
Conclusion : G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women.
Keywords
XRCC2, RAD51, breast cancer, gene polymorphism
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