Predicting the efficacy of iodine-125 seed implantation therapy for metastatic lesions of radioiodine-refractory differentiated thyroid cancer using pre-operative PET/CT parameters: A clinical study
Department of Nuclear Medicine, Jiangxi Cancer Hospital, Jiangxi, 335000, China
J Contemp Brachytherapy 2026
Data publikacji online: 2026/08/17
Article file
- Schlumberger M, Brose M, Elisei R et al. Definition and management of radioactive iodine-refractory differentiated thyroid cancer. Lancet Diabetes Endocrinol 2014; 2: 356-358.
- Rivera M, Ghossein RA, Schoder H et al. Histopathologic characterization of radioactive iodine-refractory fluorodeoxyglucose-positron emission tomography-positive thyroid carcinoma. Cancer 2008; 113: 48-56.
- Lin YS, Wang RF, Huang R et al. Chinese management guidelines for radioactive iodine-refractory differentiated thyroid cancer (2025 edition). Eur J Nucl Med Mol Imaging 2025; 52: 3859-3876.
- Hou Y, Liu R, Cui Y et al. Short-term effectiveness and safety of CT-guided radioactive iodine-125 seed implantation for treatment of adrenal metastases. J Contemp Brachytherapy 2022; 14: 148-156.
- Cheng G, Wang Y, Dong D et al. To evaluate the efficacy and safety of 125I seed implantation in SCLC as second line therapy. Medicine (Baltimore) 2022; 101: e29251.
- Zhang Y, Liang Y, Liu Z et al. Efficacy of radioactive 125I seed implantation in treating inoperable or refused operation head and neck cancers. J Cancer Res Ther 2024; 20: 642-650.
- Schurink NW, van Kranen SR, Berbee M et al. Studying local tumour heterogeneity on MRI and FDG-PET/CT to predict response to neoadjuvant chemoradiotherapy in rectal cancer. Eur Radiol 2021; 31: 7031-7038.
- Khiewvan B, Torigian DA, Emamzadehfard S et al. Update of the role of PET/CT and PET/MRI in the management of patients with cervical cancer. Hell J Nucl Med 2016; 19: 254-268.
- Krengli M, Ferrara E, Guaschino R et al. 18F-FDG PET/CT as predictive and prognostic factor in esophageal cancer treated with combined modality treatment. Ann Nucl Med 2022; 36: 450-459.
- Feng X, Wen X, Li L et al. Baseline total metabolic tumor volume and total lesion glycolysis measured on 18F-FDG PET-CT predict outcomes in T-cell lymphoblastic lymphoma. Cancer Res Treat 2021; 53: 837-846.
- Committee of Minimally Invasive Therapy in Oncology, Chinese Anti-Cancer Association; Committee of Experts on Radioactive Particle Implantation, Chinese Medical Doctor Association. Chinese expert consensus on iodine-125 seed implantation for locally advanced differentiated thyroid cancer (2023 edition). Zhonghua Yi Xue Za Zhi 2023; 103: 149-157. Chinese.
- Ji Z, Jiang Y, Tian S et al. The effectiveness and prognostic factors of CT-guided radioactive I-125 seed implantation for the treatment of recurrent head and neck cancer after external beam radiation therapy. Int J Radiat Oncol Biol Phys 2019; 103: 638-645.
- Chen Y, Jiang Y, Ji Z et al. Dosimetry, efficacy, and safety of three-dimensional printing noncoplanar template-assisted and CT-guided (125)I seed implantation for recurrent retroperitoneal lymphatic metastasis after external beam radiotherapy. Brachytherapy 2020; 19: 380-388.
- Qu A, Jiang P, Sun H et al. Efficacy and dosimetry analysis of image-guided radioactive 125I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol 2019; 30: e9.
- Xu K, Tian C, Liu Y et al. Is iodine-125 seed strand brachytherapy suitable for ureteral carcinoma? Urol Oncol 2022; 40: 537.e11-537.e17.
- Han HM, Zhao XX, Shi LJ et al. Clinical efficacy and safety analysis of 125I seed implantation in the treatment of mediastinal lymph node metastasis of lung cancer. Zhonghua Yi Xue Za Zhi 2023; 103: 1781-1786. Chinese.
- Zhang Y, Liu Z, Liang Y et al. The effectiveness and prognostic factors of radioactive iodine-125 seed implantation for the treatment of cervical lymph node recurrence of esophageal squamous cell carcinoma after external beam radiation therapy. J Contemp Brachytherapy 2020; 12: 579-585.
- Martens RM, Noij DP, Koopman T et al. Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy. Eur J Radiol 2019; 113: 39-50.
- Cselik Z, Tóth Z, Kedves A et al. Predictive value of PET/CT based metabolic information in the modern 3D based radiotherapy treatment of head and neck cancer patients – single institute study. Hell J Nucl Med 2020; 23: 290-295.
- Chen Z, Nath R. Biologically effective dose (BED) for interstitial seed implants containing a mixture of radionuclides with different half-lives. Int J Radiat Oncol Biol Phys 2003; 55: 825-834.
- Du P, Xiao Y, Lu W. Modified fan-shaped distribution technology for computed tomography (CT)-guided radioactive seed implantation in lung cancer patients with lung dysfunction. Med Sci Monit 2017; 23: 4366-4375.
- Cao G, Chang X, Wang Z et al. Dose and local efficacy analysis of iodine-125 seed implantation therapy for lung tumors. Front Oncol 2025; 15: 1589325.
- Shen LF, Zhou SH, Yu Q. Predicting response to radiotherapy in tumors with PET/CT: when and how? Transl Cancer Res 2020; 9: 2972-2981.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
