Abstract
4/2005
vol. 4
The case of using antiangiogenic agent – plasmide vector psFLT and radiochemotherapy in locally advanced vulvar cancer
Prz Menopauz 2005; 4: 17–21
Online publish date: 2005/08/31
This is a case report documenting a successful use of antiangiogenic agent- plasmide vector psFLT with successive chemo-radiotherapy and radical surgery in patient with primarily unoperable invasive carcinoma of the vulva.
After 3 courses of subcutaneous injection of 30 micrograms of Plasmide vector psFLTa significant reduction of the tumor size was obtained.
Subsequently chemo-irradiation was 5-Fluorouracil and Mitomycin-C was carried out resulting in complete clinical regression of the tumor. Radical vulvectomy and inguino-femoral limphadenectomy was performed 6 weeks after completion of chemo-irradiation. Microscopic examination of the specimen revealed a complete eradication of the malignant tissue.
The case demonstrates a significant potential of antiangiogenic therapy combiened with chemo-irradiation for locally advanced carcinoma of the vulva. This experimental method of treatment deserves further investigation.
After 3 courses of subcutaneous injection of 30 micrograms of Plasmide vector psFLTa significant reduction of the tumor size was obtained.
Subsequently chemo-irradiation was 5-Fluorouracil and Mitomycin-C was carried out resulting in complete clinical regression of the tumor. Radical vulvectomy and inguino-femoral limphadenectomy was performed 6 weeks after completion of chemo-irradiation. Microscopic examination of the specimen revealed a complete eradication of the malignant tissue.
The case demonstrates a significant potential of antiangiogenic therapy combiened with chemo-irradiation for locally advanced carcinoma of the vulva. This experimental method of treatment deserves further investigation.
Keywords
vulvar cancer, angiogenesis inhibitors, chemo-irradiation
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