Przegląd Gastroenterologiczny
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1/2026
vol. 21
 
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Artykuł oryginalny

Study of serum long non-coding RNA interferon gamma antisense-1 as a biomarker of activity in Crohn’s disease

Doaa Abdou Header
1
,
Abeer Mahmoud Ali Ibrahim
1
,
Asmaa Mahdy Ramadan
1
,
Fatma Ibrahim Dwedar
2
,
Khaled Abdel Aty
1

  1. Internal Medicine Department, Gastroenterology Unit, Faculty of Medicine, Alexandria University, Egypt
  2. Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Egypt
Gastroenterology Rev 2026; 21 (1): 82–87
DOI: https://doi.org/10.5114/pg.2026.160534
Data publikacji online: 2026/03/26
Plik artykułu:
- Study of serum.pdf  [0.10 MB]
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Metryki PlumX:
 
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2. Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 7th ed. Saunders, Philadelphia 2002; 98.
3. Henriksen M, Jahnsen J, Lygren I, et al. Change of diagnosis during the first five years after onset of inflammatory bowel disease: results of a prospective follow-up study (the IBSEN Study). Scand J Gastroenterol 2006; 41: 1037-43.
4. Jess T, Riis L, Vind I, et al. Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark. Inflamm Bowel Dis 2007; 13: 481-9.
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10. Wang L, Xie Y, Chen W, et al. The role of long noncoding RNAs in livestock adipose tissue deposition – a review. Anim Biosci 2021; 34: 1089-99.
11. Ruan X, Li P, Chen Y, et al. In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits. Nat Commun 2020; 11: 45.
12. Yaghoobi H, Azizi H, Oskooei VK, et al. Assessment of expression of interferon g (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer. World J Surg Oncol 2018; 16: 211.
13. Collier SP, Collins PL, Williams CL, et al. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol 2012; 189: 2084-8.
14. Collier SP, Henderson MA, Tossberg JT, et al. Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet. J Immunol 2014; 193: 3959-65.
15. Chen S, He R, He B, et al. Potential roles of exosomal lncRNAs in the intestinal mucosal immune barrier. J Immunol Res 2021; 2021: 7183136.
16. Zheng ZK, Pang C, Yang Y, et al. Serum long noncoding RNA urothelial carcinoma-associated 1: a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. J Int Med Res 2018; 46: 348-56.
17. Xie H, Ma H, Zhou D. Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. BioMed Res Int 2013; 2013: 136106.
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19. Rankin CR, Shao L, Elliott J, et al. The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. Am J Physiol Gastrointest Liver Physiol 2020; 318: G34-40.
20. Padua D, Mahurkar-Joshi S, Law IK, et al. A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. Am J Physiol Gastrointest Liver Physiol 2016; 311: G446-57.
21. Huang Q, Shi CM, Miao YL, et al. Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis. Eur Rev Med Pharmacol Sci 2020; 24: 7345-56.
22. Li C, Cui L, Li S, et al. Long non‑coding RNA Mirt2 interacts with long non‑coding RNA IFNG‑AS1 to regulate ulcerative colitis. Exp Ther Med 2020; 20: 32.
23. Raza A, Ahmed K, Navaneethan U, et al. Significant correlation between interferon-g (IFN-g) secretion by T cells in peripheral blood with disease severity in Crohn’s disease but not in ulcerative colitis: 1564. Am J Gastroenterol 2012; 107: S630.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.



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