eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
4/2012
vol. 16
 
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abstract:
Review paper

Surveillance programs for early detection of hepatocellular carcinoma

Krzysztof Simon
,
Sylwia Serafińska
,
Monika Pazgan-Simon

Wspolczesna Onkol 2012; 16 (4): 295–299
[Polish version: Wspolczesna Onkol 2012; 16 (4): 300–305]
Online publish date: 2012/09/29
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Primary hepatocellular carcinoma (HCC) is the most commonly diagnosed primary malignancy of the liver. The number of new diagnosed cases of HCC seems to be on a rise worldwide. HCC is typically diagnosed in patients with underlying liver cirrhosis (> 90% cases) regardless of aetiology; over a five-year follow-up period HCC develops in 15–20% of patients with cirrhosis. Patients who are at a high risk of HCC development (i.e. individuals with liver cirrhosis, especially/or chronically infected with HBV or HCV) should undergo regular screening for HCC; the current screening standard comprises liver ultrasonography and determination ofα α-fetoprotein (AFP) concentration in blood serum at ca.

6 months’ intervals (now has been excluded from current diagnostic standards). Only such diagnostic methods are capable of detecting HCC early, and thus make it possible to treat the cancer effectively.
keywords:

hepatocellular carcinoma, liver cirrhosis, HBV and HCV infection, screening tests, α-fetoprotein

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