eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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www.egastroenterologia.pl
SCImago Journal & Country Rank
3/2019
vol. 14
 
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Artykuł oryginalny

The importance of complete blood count parameters in the screening of gastric cancer

Evrim Kahramanoğlu Aksoy
1
,
Selen Kantarci
2
,
Murat Torgutalp
3
,
Muhammet Yener Akpinar
1
,
Ferdane Pirinççi Sapmaz
1
,
Gülsüm Şeyma Yalçın
4
,
Metin Uzman
1
,
Gülçin Güler Şimşek
4
,
Yaşar Nazlıgül
1

1.
Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey
2.
Department of Internal Medicine, Keçiören Training and Research Hospital, Ankara, Turkey
3.
Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey
4.
Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey
Data publikacji online: 2019/09/27
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Introduction
Gastric cancer is ranked fourth among all cancers in the world and second in cancer-related deaths. Gastritis leads to the activation of neutrophils, lymphocytes, macrophages, and platelets. Long-term inflammation leads to multistage histopathologic changes called Correa tract, which includes gastritis, atrophy, intestinal metaplasia (IM), dysplasia, and cancer stages.

Aim
To determine if there is any difference in haematological parameters between gastric cancer (GC) patients, patients with IM, and healthy controls (HC).

Material and methods
Seventy-three GC patients, 79 patients with IM, and 70 HCs were included in the study. Demographics and laboratory parameters of complete blood count were extracted from the hospital medical database records.

Results
The mean Hb levels were statistically significant between all three groups. Mean red cell distribution width (RDW), white blood cells (WBC), mean platelet volume (MPV), platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and monocyte-to-lymphocyte (MLR) levels were statistically significantly different between gastric cancer and healthy controls. Mean RDW, MPV, and PDW levels were statistically significantly different between the IM and healthy control groups. Mean WBC, NLR, PLR, and MLR levels were statistically significantly different between the gastric cancer and IM groups.

Conclusions
RDW, platelet count, NLR, MLR, and PLR have diagnostic value and can help to distinguish patients with GC from those with IM. These parameters are accessible easily, the cost is not high, and it may help patients not to delay endoscopic screening.

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