Alergologia Polska - Polish Journal of Allergology
eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
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abstract:
Special paper

The limited clinical relevance and potential risks associated with the diagnosis of histamine intolerance in children: a position statement of the Food Allergy Section of the Polish Society for Pediatric Gastroenterology, Hepatology and Nutrition and the Pediatric Section of the Polish Society of Allergology

Andrea Horvath
1
,
Agata Stróżyk
1
,
Adam Sybilski
2, 3
,
Małgorzata Frajberg
4
,
Elżbieta Jarocka-Cyrta
5
,
Piotr Dziechciarz
6
,
Katarzyna Plata-Nazar
7
,
Agnieszka Krauze
8
,
Łukasz Błażowski
9

  1. Department of Pediatrics, Medical University of Warsaw, Poland
  2. Department of Pediatrics and Allergology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland
  3. 2nd Department of Pediatrics, Centre of Postgraduate Medical Education, Warsaw, Poland
  4. PRIMA Specialist Outpatient Clinic, Warsaw, Poland
  5. Department of Pediatrics, Gastroenterology and Nutrition, University of Warmia and Mazury, Children’s Specialist Hospital, Olsztyn, Poland
  6. Department of Research Methodology, Medical University of Warsaw, Poland
  7. Department and Clinic of Pediatrics, Gastroenterology, Allergology and Child Nutrition, Medical University of Gdansk, Poland
  8. City Clinic, Warsaw, Poland
  9. Collegium Medicum, University of Rzeszow, Poland
Alergologia Polska – Polish Journal of Allergology
DOI: https://doi.org/10.5114/pja.2026.161657
Online publish date: 2026/05/12
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The aim of this paper is to provide a critical analysis of histamine intolerance (HIT) in children and adolescents, with a focus on proposed mechanisms, diagnostic limitations, and realistic therapeutic options. Symptoms attributed to HIT are nonspecific and therefore require a broad differential diagnosis, including functional and psychosomatic disorders, allergies, other food intolerances, and inflammatory diseases. Measurement of serum diamine oxidase activity has limited diagnostic utility. If dietary intervention is considered, it should be short-term and accompanied by an assessment of the risk of nutritional deficiencies and the potential development of pediatric feeding and eating disorders. The overarching goal should remain the maintenance of dietary diversity and the improvement of quality of life for the child and their family. This paper also highlights the need for high-quality research and effective patient and family education to reduce misdiagnosis and prevent unnecessary dietary restrictions.
keywords:

histamine intolerance, diagnosis, children



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