Alergologia Polska - Polish Journal of Allergology

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2/2026 vol. 13
Review paper

The role of microbiota metabolites in the regulation of immune responses in allergic diseases

  1. Department of Pathological Anatomy and Histopathology, N. Copernicus Memorial Hospital, Medical University of Lodz, Poland

  2. Department of Immunopathology, Medical University of Lodz, Poland

Alergologia Polska – Polish Journal of Allergology 2026; 13, 2: 150–160


Data publikacji online: 2026/06/23
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The role of microbiota.pdf
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  1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259-60.
  2. Bloomfield SF, Stanwell-Smith R, Crevel RW, Pickup J. Too clean, or not too clean: the hygiene hypothesis and home hygiene. Clin Exp Allergy 2006; 36: 402-25.
  3. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell 2014; 157: 121-41.
  4. Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med 2016; 375: 2369-79.
  5. Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 2016; 165: 1332-45.
  6. Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage AhR and balance mucosal reactivity. Immunity 2013; 39: 372-85.
  7. Hang S, Paik D, Yao L, et al. Bile acid metabolites control Th17 and Treg cell differentiation. Nature 2019; 576: 143-8.
  8. Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504: 451-5.
  9. Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces differentiation of colonic regulatory T cells. Nature 2013; 504: 446-50.
  10. Wypych TP, Wickramasinghe LC, Marsland BJ. The influence of the microbiome on respiratory health. Nat Med 2019; 25: 1830-41.
  11. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science 2012; 336: 1268-73.
  12. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses. Nat Rev Immunol 2009; 9: 313-23.
  13. Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Nature 2011; 500: 232-6.
  14. Sommer F, Bäckhed F. The gut microbiota – masters of host development and physiology. Nat Rev Microbiol 2013; 11: 227-38.
  15. Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science 2012; 336: 1262-7.
  16. Tan J, McKenzie C, Potamitis M, et al. The role of short-chain fatty acids in health and disease. Adv Immunol 2014; 121: 91-119.
  17. Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease. Nat Med 2014; 20: 159-66.
  18. Thorburn AN, McKenzie CI, Shen S, et al. Evidence that asthma is a developmental origin disease influenced by microbiota. Nat Commun 2015; 6: 7320.
  19. Agus A, Planchais J, Sokol H. Gut microbiota regulation of tryptophan metabolism in health and disease. Nat Rev Microbiol 2018; 16: 289-305.
  20. Roager HM, Licht TR. Microbial tryptophan catabolites in health and disease. Nat Commun 2018; 9: 3294.
  21. Wypych TP, Marsland BJ, Ubags NDJ. The impact of the microbiome on respiratory health. Nat Med 2019; 25: 1830-41.
  22. Song X, Sun X, Oh SF, et al. Microbial bile acid metabolites regulate host immunity. Nature 2020; 577: 410-5.
  23. Park BS, Lee JO. Recognition of lipopolysaccharide pattern by TLR4 complexes. Annu Rev Biochem 2013; 82: 537-61.
  24. Cait A, Hughes MR, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol 2018; 11: 785-95.
  25. Bischoff SC, Barbara G, Buurman W, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014; 14: 189.
  26. Yu B, Pei C, Peng W, et al. Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production. Sig Transduct Target Ther 2025; 10: 181.
  27. GINA. Global Initiative for Asthma – GINA. Global Strategy for Asthma Management and Prevention, 2025. Updated 15 November 2025. [Online] [Cited: 21 04 2026.] https://ginasthma.org/faq/#.
  28. Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota and childhood asthma. Sci Transl Med 2016; 8: 343-82.
  29. Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect asthma risk. Sci Transl Med 2015; 7: 307ra152.
  30. Januszkiewicz E, Mierzejewski M, Biniszewska O, et al. The importance of the gut microbiome in the development of allergic diseases. Pol J Allergol 2023; 10: 202-9.
  31. Marko M, Pawliczak R. Mistakes in the diagnosis and treatment of atopic dermatitis. Pol J Allergol 2024; 11: 61-8.
  32. Cuello-Garcia CA, Brożek JL, Fiocchi A, et al. Probiotics for the prevention of allergy. J Allergy Clin Immunol 2015; 136: 952-61.
  33. Gibson GR, Hutkins R, Sanders ME, et al. The concept of prebiotics. Nat Rev Gastroenterol Hepatol 2017; 14: 491-502.
  34. Kim CH, Baker JR. Regulation of allergies across the body by microbial metabolites. Exp Mol Med 2026; 58: 396-407.
  35. Wang H, He Y, Dang D, et al. Gut microbiota-derived tryptophan metabolites alleviate allergic diseases. Foods 2024; 13: 1336.
  36. Yip W, Hughes MR, Li Y, et al. Butyrate shapes immune cell fate and function in allergic asthma. Front Immunol 2021; 12: 628453.
  37. Sepahi A, Liu Q, Friesen L, Kim CH. Dietary fiber metabolites regulate innate lymphoid cell responses. Mucosal Immunol 2021; 14: 317-30.
  38. Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, et al. Postbiotics: an evolving concept. Trends Food Sci Technol 2018; 75: 105-14.
  39. Salminen S, Collado MC, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics definition of postbiotics. Nat Rev Gastroenterol Hepatol 2021; 18: 649-67.
  40. Zmora N, Suez J, Elinav E. Personalized gut microbiome therapy. Cell 2018; 174: 1327-39.
  41. Knight R, Vrbanac A, Taylor BC, et al. Best practices for microbiome studies. Nat Rev Microbiol 2018; 16: 410-22.
  42. Wishart DS. Emerging applications of metabolomics in drug discovery. Nat Rev Drug Discov 2016; 15: 473-84.
  43. Rothschild D, Weissbrod O, Barkan E, et al. Environment dominates over host genetics in shaping microbiota. Nature 2018; 555: 210-5.
  44. Lloyd-Price J, Arze C, Ananthakrishnan AN, et al. Multi-omics of the gut microbiome. Nature 2019; 569: 655-62.
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