Full text
3/2026
vol. 13
Case report
Transient immunological abnormality in a patient undergoing thymectomy for congenital heart disease correction
Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya, Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye
Alergologia Polska – Polish Journal of Allergology 2026; 13, 3: 273-278
Data publikacji online: 2026/10/06
- Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890-900.
- van der Linde D, Konings EE, Slager MA, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 2011; 58: 2241-7.
- Jaworski R, Haponiuk I, Irga N, et al. Makroskopowe zmiany w grasicy u dziecka leczonego kardiochirurgicznie – znaczenie oceny śródoperacyjnej w rozpoznaniu histiocytozy. Kardiochir Torakochir Pol 2011; 8: 475-7.
- Diller GP, Arvanitaki A, Opotowsky AR, et al. Lifespan perspective on congenital heart disease research: JACC state-of-the-art review. J Am Coll Cardiol 202; 77: 2219-235.
- Brearley S, Gentle TA, Baynham MI, et al. Immunodeficiency following neonatal thymectomy in man. Clin Exp Immunol 1987; 70: 322-7.
- Silva SL, Albuquerque A, Amaral AJ, et al. Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. PLoS One 2017; 12: e0180385.
- van den Broek T, Madi A, Delemarre EM, et al. Human neonatal thymectomy induces altered B-cell responses and autoreactivity. Eur J Immunol 2017; 47: 1970-81.
- Gudmundsdottir J, Óskarsdóttir S, Skogberg G, et al. Early thymectomy leads to premature immunologic ageing: an 18-year follow-up. J Allergy Clin Immunol 2016; 138: 1439-43.e10.
- van den Broek T, Delemarre EM, Janssen WJ, et al. Neonatal thymectomy reveals differentiation and plasticity within human naive T cells. J Clin Invest 2016; 126: 1126-36.
- Gudmundsdottir J, Söderling J, Berggren H, et al. Long-term clinical effects of early thymectomy: associations with autoimmune diseases, cancer, infections, and atopic diseases. J Allergy Clin Immunol 2018; 141: 2294-7.e8.
- van Gent R, Schadenberg AW, Otto SA, et al. Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration? Blood 2011; 118: 627-34.
- van den Broek T, Madi A, Delemarre EM, et al. Human neonatal thymectomy induces altered B-cell responses and autoreactivity. Eur J Immunol 2017; 47: 1970-81.
- Eysteinsdottir JH, Freysdottir J, Haraldsson A, et al. The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life. Clin Exp Immunol 2004; 136: 349-55.
- Kurobe H, Tominaga T, Sugano M, et al. Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery. J Thorac Cardiovasc Surg 2013; 145: 656-62, 662.e1-2.
- Mancebo E, Clemente J, Sanchez J, et al. Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery. Clin Exp Immunol 2008; 154: 375-83.
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