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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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vol. 10
Case report

Transitional cell carcinoma of endometrium: a case report of rare pure form

Francesco Cuccia, Gianluca Mortellaro, Antonio Spera, Giovanna Evangelista, Antonio Lo Casto, Giuseppe Ferrera

J Contemp Brachytherapy 2018; 10, 5: 483–485
Online publish date: 2018/10/31
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Transitional cell carcinoma is a very rare histological subtype of endometrial cancer, with only 18 cases described in literature. Ovary represents the most common site where it accounts for 2% of all ovarian cancers. Due to the rarity of this disease, current management is controversial and includes various approaches, mostly described in the adjuvant setting, both radiotherapy and chemotherapy alone or in combination. Here, we report a case of a 65-year-old patient who underwent adjuvant vaginal brachytherapy for an endometrial transitional cell carcinoma. The patient was treated with radical total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH-BSO), without lymph-node sampling, and adjuvant endocavitary brachytherapy delivering 30 Gy in 5 fractions in consecutive days. Treatment tolerance was excellent, with only G1 genitourinary acute toxicity and no other adverse events reported. In this experience, the choice of brachytherapy alone resulted in excellent local control outcomes. However, the patient developed a distant recurrence after 43 months and chemotherapy was applied. More research is required to determine the most effective treatment for this rare histological subtype, and in particular, the role of chemotherapy and radiotherapy combinations.

brachytherapy, endometrium, gynecology, transitional cell carcinoma

De Cecio R, Cantile M, Collina F et al. Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study. J Ovar Res 2014; 7: 101.
Chen KT. Extraovarian transitional cell carcinoma of female genital tract. Am J Clin Pathol 1990; 94: 670-671.
Spiegel GW, Austin RM, Gelven PL. Transitional cell carcinoma of the endometrium. Gynecol Onc 1996; 60: 325-330.
Lininger RA, Ashfaq R, Albores-Saavedra J et al. Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation. Cancer 1997; 79: 1933-1943.
Fukunaga M, Ushigome S. Transitional cell carcinoma of the endometrium. Histopathology 1998; 32: 284-286.
Labonté S, Têtu B, Boucher D et al. Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. Hum Pathol 2001; 32: 230-232.
Mariño-Enríquez A, González-Rocha T, Burgos E et al. Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation: a clinicopathologic study of 5 cases and review of the literature. Hum Pathol 2008; 39: 1606-1613.
Ahluwalia M, Light AM, Surampudi K et al. Transitional cell carcinoma of the endometrium: a case report and review of the literature. Int J Gynecol Pathol 2006; 25: 378-382.
Ribeiro-Silva A. Immunohistochemical features of a papillary squamous cell carcinoma of the endometrium with transitional cell differentiation. Diagn Pathol 2007; 2: 26.
Lum D. Primary transitional cell carcinoma of the endometrium. Pathology 2005; 7: 554-557.
Koh WJ, Abu-Rustum NR, Bean S et al. Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2018; 16: 170-199.
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