One third of a woman’s life is around or after the menopause. Nowadays a 50-year old woman is a full-time working person expected to be fully active in intellectual, physical and social terms. The study focuses on the area of cognitive dysfunction among women after the menopause. It determines their participation in professional, family and social life.

The study is a review of literature on the role hormonal changes play in originating cognitive dysfunction after the menopause and potential modification of neuropsychogenic function by estrogens depending on the selected gene polymorphisms. It hypothesises that estrogen deficiency and variations in LH level may initiate cognitive dysfunction. The authors are inclined to consider this because of the not fully understood processes of hormonal axis dysfunction in connection with progressive disorder of cognitive function over time. This results in lack of uniform standards of preventive measures and treatment of such health problems in this group of patients.

Assessment of cognitive dysfunction in this group of patients and their correlation with a type of hormonal dysfunction, gene polymorphism or environmental conditions such as health behavior and diet, would facilitate actions leading to adequate prophylaxis, improvement quality of life as well as proposing new forms and methods of therapy. In the longer term this would be positive in health, economic and social terms.