eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2017
vol. 34
 
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abstract:
Original paper

Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

Bengu Cevirgen Cemil
,
Demet Yilmazer
,
Hatice Atas
,
Fatma Pelin Cengiz
,
Filiz Canpolat
,
Murat Alper
,
Muzeyyen Gonul

Adv Dermatol Allergol 2017; XXXIV (4): 322–327
Online publish date: 2017/08/01
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Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.


Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.


Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.


Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.


Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
keywords:

corticotropin-releasing hormone, hypothalamo-hypophyseal system, lichen planus, receptors, skin Introduction

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