The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection

Ljiljana Božić; Darija Knežević; Maja Travar; Nataša Miljuš; Miroslav Petković; Jela Aćimović; Jelena Djaković Dević; Miloš P. Stojiljković; Dejan Bokonjić; Ranko Škrbić

doi:10.5114/ceji.2023.125239

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Short communication

The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection

Ljiljana Božić

^{1, 2}

,

Darija Knežević

^{1, 2}

,

Maja Travar

²

,

Nataša Miljuš

¹

,

Miroslav Petković

²

,

Jela Aćimović

³

,

Jelena Djaković Dević

³

,

Miloš P. Stojiljković

¹

,

Dejan Bokonjić

⁴

,

Ranko Škrbić

¹

Centre for Biomedical Research, Faculty of Medicine, University of Banja Luka, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina
Department of Microbiology, Faculty of Medicine, University of Banja Luka, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina
Public Health Institute of the Republic of Srpska, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina
Faculty of Medicine Foča, University of East Sarajevo, East Sarajevo, The Republic of Srpska, Bosnia and Herzegovina

Cent Eur J Immunol 2023; 48 (1): 35-42

DOI: https://doi.org/10.5114/ceji.2023.125239

Online publish date: 2023/02/23

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AMA

Božić L, Knežević D, Travar M, et al. The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection. Central European Journal of Immunology. 2023;48(1):35-42. doi:10.5114/ceji.2023.125239.

APA

Božić, L., Knežević, D., Travar, M., Miljuš, N., Petković, M.,  & Aćimović, J. et al. (2023). The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection. Central European Journal of Immunology, 48(1), 35-42. https://doi.org/10.5114/ceji.2023.125239

Chicago

Božić, Ljiljana, Darija Knežević, Maja Travar, Nataša Miljuš, Miroslav Petković, Jela Aćimović,  and Jelena Djaković Dević et al. 2023. "The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection". Central European Journal of Immunology 48 (1): 35-42. doi:10.5114/ceji.2023.125239.

Harvard

Božić, L., Knežević, D., Travar, M., Miljuš, N., Petković, M., Aćimović, J., Dević, J., Stojiljković, M., Bokonjić, D.,  and Škrbić, R. (2023). The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection. Central European Journal of Immunology, 48(1), pp.35-42. https://doi.org/10.5114/ceji.2023.125239

MLA

Božić, Ljiljana et al. "The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection." Central European Journal of Immunology, vol. 48, no. 1, 2023, pp. 35-42. doi:10.5114/ceji.2023.125239.

Vancouver

Božić L, Knežević D, Travar M, Miljuš N, Petković M, Aćimović J et al. The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared 
to the natural infection. Central European Journal of Immunology. 2023;48(1):35-42. doi:10.5114/ceji.2023.125239.

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Introduction:
During the last two and a half years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread around the world. Most of the SARS-CoV-2 vaccines are designed to produce anti-SARS-CoV-2 immunoglobulin G (IgG) against the viral S-glycoprotein. The aim of this study was to measure the anti-S antibody titres among the medical personnel who had been fully vaccinated with different types of vaccines, and to compare them with those who were COVID-19 convalescents.

Material and methods:
In this study serum was collected from 261 healthcare workers, of whom 227 were vaccinated, while 34 were recovered participants who were not immunised. Serum samples were collected 21 days after the first dose and 60 and 180 days after the second dose of the vaccines and tested with a commercial ELISA kit.

Results:
The highest antibody level (12 AU/ml) was measured in the Pfizer-BioNTech group, followed by Sinopharm (9.3 AU/ml), Sputnik V (5.9 AU/ml), Sinovac (4.6 AU/ml) and Oxford/Astra- Zeneca vaccine (2.5 AU/ml) 60 days after the second dose of the vaccines (90 days after the first dose). The seropositivity rate for mRNA vaccine was 88.5%, for vector vaccines 86.2% and for inactivated vaccines 71.4%. When comparing these antibody levels with COVID-19 convalescents, higher antibody titres were found in vaccinated participants (5.76 AU/ml vs 7.06 AU/ml), but the difference was not significant (p = 0.08).

Conclusions:
Individuals vaccinated with mRNA and vector vaccines had a higher seroconversion rate compared to the group vaccinated with inactivated vaccines, or convalescents.

keywords:

The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection

Ljiljana Božić 1, 2 , Darija Knežević 1, 2 , Maja Travar 2 , Nataša Miljuš 1 , Miroslav Petković 2 , Jela Aćimović 3 , Jelena Djaković Dević 3 , Miloš P. Stojiljković 1 , Dejan Bokonjić 4 , Ranko Škrbić 1

COVID-19, IgG antibody, immunity, SARS-CoV-2, vaccines

Ljiljana Božić

^{1, 2}

,

Darija Knežević

^{1, 2}

,

Maja Travar

²

,

Nataša Miljuš

¹

,

Miroslav Petković

²

,

Jela Aćimović

³

,

Jelena Djaković Dević

³

,

Miloš P. Stojiljković

¹

,

Dejan Bokonjić

⁴

,

Ranko Škrbić

¹