eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2011
vol. 36
 
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abstract:

Clinical immunology
The estimation of B7 family molecule expression on dendritic cells generated from CLL patients

Paulina Wdowiak
,
Magdalena Wasiak
,
Jacek Tabarkiewicz
,
Iwona Hus
,
Elżbieta Drab
,
Anna Dmoszyńska
,
Jacek Roliński

(Centr Eur J Immunol 2011; 36 (1): 33-36)
Online publish date: 2011/03/31
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T cell and B cell activation is dependent upon signals delivered through the antigen-specific T or B cell receptors. The ultimate immune response is determined by costimulatory signals which are supplied through molecules that belong to B7 family. The molecules B7.1 (CD80) and B7.2 (CD86) and interactions with their receptors CD28 and CTLA-4 constitute costimulatory and coinhibitory system which regulate immune response. This signals promote initial lymphocytes activation and regulate self-tolerance. The B7 ligands, B7-H1, B7-DC, B7-H3 and B7-H4 are expressed on profesional antigen presenting cells. This molecules are expressed both in lymphoid and non-lymphoid tissues. B7-H4 is recently identified molecule from B7 family. It appears that B7-H4 protein is expressed in many cancers such as breast, ovarian and lung cancer and it may influence tumor-specific T-cell responses in cancer patients. B7 family members may play an important role in the development of autoimmune and immunodeficiency diseases. Understanding of pathways, mechanisms of action and functions of these ligands may contribute to the development of novel strategies for the treatment of immune-mediated diseases.

Dendritic cells (DCs) are the most effective antigen presenting cells (APC) and play a crucial role in the initiation and regulation of immune responses against a variety of antigens, including tumor-specific antigens.
keywords:

B7 family molecule, dendritic cells, CLL


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