eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2011
vol. 36
 
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abstract:

Clinical immunology
The role of TACI expression in chronic lymphocytic leukemia

Agnieszka Bojarska-Junak
,
Iwona Hus
,
Małgorzata Sieklucka
,
Agata Surdacka
,
Maria Luiza Kusz
,
Ewa Wąsik-Szczepanek
,
Anna Dmoszyńska
,
Jacek Roliński

(Centr Eur J Immunol 2011; 36 (1): 46-50)
Online publish date: 2011/03/31
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Transmembrane activator and CAML interactor (TACI) was identified as a receptor for BAFF and APRIL, two members of TNF ligand family. The significantly lower TACI expression on B cells from CLL patients than from normal controls raised the question of the importance of TACI in CLL pathogenesis. We investigated the relationship between TACI expression and pro- and antiapoptotic proteins expression in CLL cells. Moreover, we were interested in a possible relationship between TACI expression and prognostic factors such as: CD38 antigen or ZAP-70 protein expression, which are known poor prognosis factors in B-CLL. Our results confirm the significance of apoptosis deregulation in CLL and suggest the possible relationship between TACI expression and the clinical course of the disease.
keywords:

CLL, TACI, ZAP-70, PAR-4, DAXX, ZIPK, apoptosis


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