Experimental immunology 
In vitro effect of cadmium on the function of human lymphocytes and neutrophils

Barbara Poniedziałek; Piotr Rzymski; Krzysztof Wiktorowicz

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2012
vol. 37

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abstract:

Experimental immunology
In vitro effect of cadmium on the function of human lymphocytes and neutrophils

Barbara Poniedziałek

,

Piotr Rzymski

,

Krzysztof Wiktorowicz

(Centr Eur J Immunol 2012; 37 (2): 110-113)

Online publish date: 2012/05/22

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Cadmium (Cd) is a heavy metal which is one of the most serious environmental pollutants. Exposure pathways include contaminated water, food and air pollution. Controversial results of Cd effect on immune response have been shown and its potential immunosuppressive action is still a subject of study. We investigated Cd effect in different concentrations on human peripheral lymphocytes proliferation and reactive oxygen species (ROS) production in neutrophils. Cadmium caused significant lower lymphocytes proliferation rate and decrease of ROS production in high concentrations (100 µM). Our and other works indicate that cadmium effect on immune response cannot be excluded and might widely differ in human population.

keywords:

Experimental immunology In vitro effect of cadmium on the function of human lymphocytes and neutrophils

Barbara Poniedziałek , Piotr Rzymski , Krzysztof Wiktorowicz

cadmium, peripheral blood lymphocytes, proliferation, reactive oxygen species, neutrophils

Experimental immunology
In vitro effect of cadmium on the function of human lymphocytes and neutrophils

Barbara Poniedziałek

,

Piotr Rzymski

,

Krzysztof Wiktorowicz