eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2011
vol. 36
 
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abstract:

Experimental immunology
The proliferation rate and phase growth of human peripheral lymphocytes in vitro under zinc influence

Barbara Poniedziałek
,
Piotr Rzymski
,
Jacek Karczewski
,
Katarzyna Piwecka
,
Krzysztof Wiktorowicz

(Centr Eur J Immunol 2011; 36 (3): 160-162)
Online publish date: 2011/10/18
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The effect of zinc chloride (ZnCl2) upon the proliferation of human peripheral lymphocytes in vitro was investigated. Zinc chloride in four concentrations (1 μM, 10 μM, 50 μM, 100 μM) was added to the lymphocytes cultures. Results indicate that high concentrations of ZnCl2 (100 μM) slightly inhibit the proliferation of human peripheral lymphocytes in vitro. The phase of lymphocyte proliferation cycle affected by ZnCl2 was also investigated. For this purpose ZnCl2 in two concentrations (50 μM, 100 μM) was added to the cell culture in 4 different time points: at the start of the cell culture, after 4 hours, 24 hours and 48 hours of incubation. The sooner ZnCl2 was added the stronger inhibition of lymphocytes proliferation was observed; the greatest change was given by 100 μM concentration of ZnCl2.
keywords:

peripheral blood lymphocytes, proliferation, zinc

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