eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2012
vol. 37
 
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abstract:

Experimental immunology
The role of regulatory T cells in mice with experimental autoimmune uveitis – a preliminary study

Yuki Nanke
,
Nobuyuki Ishiguro
,
Toru Yago
,
Tsuyoshi Kobahigawa
,
Tokuyasu Hashida
,
Shigeru Kotake

(Centr Eur J Immunol 2012; 37 (2): 102-105)
Online publish date: 2012/05/22
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The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of experimental autoimmune uveoretinitis (EAU), a model for human uveitis, induced by the retinal antigen interphotoreceptor retinoid-binding protein (IRBP).

C57BL/6 mice were immunized with human IRBP-20 (IRBP1-20). CD4+CD25+bright T cells (Treg cells) from the peripheral blood of mice were measured using two color flow cytometry. The severity of EAU was evaluated histopathology.

Inflammation was seen on days 17 and 21. The number of Treg cells in CD4+ T cells was elevated on day 9 and decreased on day 21.

The number of Treg cells in the peripheral blood was elevated on day 9 when inflammation was not noted. Treg cells may play a pivotal role in the pathogenesis of EAU induced by IRBP.
keywords:

uveitis, ocular attack, Behçet’s disease, regulatory T, EAU

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