eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
1/2010
vol. 61
 
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abstract:

In situ hybridization for human papillomavirus

Olga Stasikowska-Kanicka
,
Marian Danilewicz
,
Małgorzata Wągrowska-Danilewicz

Pol J Pathol 2010; 1: 32-36
Online publish date: 2010/05/12
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There is increasing molecular and epidemiologic evidence that human papillomavirus (HPV) is associated with distinct subset of head and neck lesions. The aim of the present study was to evaluate a possible relationship between the presence of HPV DNA and morphological signs of HPV infections in twenty-six formalin-fixed, paraffin-embedded cases of laryngeal squamous cell carcinomas and seventeen cases of sinonasal inverted papillomas, retrieved from archival material. Ten out of twenty-six cases of cancers and eleven out of seventeen sinonasal inverted papillomas showed morphological signs of HPV infections. All cases have been analyzed using in situ hybridization. The expression of HPV DNA was noted in both examined groups of squamous cell carcinomas and in group of sinonasal inverted papillomas when the morphological signs of HPV infections were present. No significant differences in the frequency of HPV DNA expression were noted in both examined groups of cancers and inverted papillomas (with and without morphological signs of HPV infection). In conclusion, our study confirms the role of HPVs in pathogenesis of inverted papillomas and laryngeal squamous cell carcinomas. However, there is no relevant relationship between the presence of HPV DNA and morphological signs of HPV infections in studied cases.
keywords:

human papillomavirus, inverted papilloma, laryngeal cancer

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