eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2012
vol. 37
 
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abstract:

Review paper
Apolipoprotein E knockout mice: an experimental model to study inflammatory mechanisms of atherosclerosis and to screen a putative anti-atherogenic properties of drugs

Jacek Jawień
,
Rafał Olszanecki
,
Bernadeta Nowak
,
Janusz Marcinkiewicz

(Centr Eur J Immunol 2012; 37 (1): 36-44)
Online publish date: 2012/03/29
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Based on the current knowledge it is well ascertained that inflammation backgrounds the pathogenesis of atherosclerosis. Still, some open questions remain.

Animal model is an important tool to study atherogenesis. Nowadays, genetically modified mice play a pivotal role. Wild mice are highly resistant to atherosclerosis, whereas “gene-targeted” modified mice can spontaneously (even without use of high cholesterol diet) develop atherosclerosis. The best example are apolipoprotein E (apoE)-knockout mice.

In this review we will discuss usefulness of apoE-knockout mice to study the pathogenesis

of atherosclerotic lesions, especially the immune mechanisms of atherogenesis.
keywords:

atherosclerosis, apoE-knockout mice, LDL receptor-knockout mouse, animal models

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