eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2012
vol. 37
 
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abstract:

Review paper
N-acetylcysteine as an anti-oxidant and anti-inflammatory drug and its some clinical applications

Dorota Magdalena Radomska-Leśniewska
,
Piotr Skopiński

(Centr Eur J Immunol 2012; 37 (1): 57-66)
Online publish date: 2012/03/29
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N-acetylcysteine (NAC) a derivative of amino acid L-cysteine is currently used mainly as an antioxidant. Sulfhydryl group (–SH) within its molecule makes possible to directly scavenge reactive oxygen species (ROS). Indirect antioxidant action of NAC rely on augmentation of the level of reduced glutathione (GSH) – a major body’s antioxidant. Since oxidative stress takes a part in pathogenesis of a broad spectrum of diseases, NAC could became a valuable supplement to conventional treatment. N-acetylcysteine has been used as an antidote for aminophen intoxication. N-acetylcysteine seems to be promising in some pulmonary diseases and gynecological disorders. Supplementation of this antioxidant caused also positive results in some eye disorders: diabetic retinopathy, age macular degeneration, cataract and dry eye syndrome. It was also found to have some preventative capabilities in cancer, influenza and in contrast-induced nephropathy.
keywords:

N-acetylcysteine, oxidative stress, pulmonary disease, polycystic ovary syndrome, endometriosis, eye disorders, cancer, contrast-induced nephropathy

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