<i>Review paper</i><br>
Cytokines and periodontitis. Part II: tumor necrosis factor and soluble tumor necrosis factor receptor I

Sylwia Małgorzata Słotwińska

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2012
vol. 37

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abstract:

Review paper
Cytokines and periodontitis. Part II: tumor necrosis factor and soluble tumor necrosis factor receptor I

Sylwia Małgorzata Słotwińska

(Centr Eur J Immunol 2012; 37 (2): 178-181)

Online publish date: 2012/05/22

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Quantitative and qualitative studies concerning tumor necrosis factor α (TNF-α) and its receptors can prove essential for periodontal diseases diagnostics. Tumor necrosis factor is believed to be a very important mediator of inflammatory reactions and host immune response. Tumor necrosis factor α is the key cytokine of local inflammatory reaction within periodontal pocket, resulting from stimulation by bacterial factors. This cytokine initiates inflammatory process and activates mechanisms leading to periodontal tissue destruction. Another cytokine of interest in respect to periodontitis ethiopathogenesis is soluble TNF receptor I (sTNF RI). Observation of soluble TNF receptors as physiologic inhibitors of TNF led to its administration in therapeutic process as well as in therapy selected cases of aggressive periodontitis.

keywords:

Review paper Cytokines and periodontitis. Part II: tumor necrosis factor and soluble tumor necrosis factor receptor I

Sylwia Małgorzata Słotwińska

periodontitis, host response, immune system, tumor necrosis factor (TNF), soluble tumor necrosis factor receptor I (sTNF RI)

Review paper
Cytokines and periodontitis. Part II: tumor necrosis factor and soluble tumor necrosis factor receptor I