A case of irritation fibroma

A 53-year-old man was referred to the Dermatology Clinic with a 2-year history of an exophytic lesion on the tip of his tongue. He did not accept any treatment since the lesion had no subjective symptoms. The lesion developed slowly and showed no notable change in size until this visit. The patient was systemically healthy, but he had a long history of smoking for almost 30 years and at least 20 cigarettes per day. In addition, he denied any history of trauma in his oral cavity. The lesion showed a well-defined nodule with approximate 0.5 cm diameter on the tip of the tongue. The nodule was firm and presented a color resembling normal mucosa. The lesion was resected completely under local anaesthesia. The tissue sample of the lesion was subjected to histopathological examination. Histological features showed hyperkeratosis, hyperplasia of epidermis, proliferation of fibroblasts and hyaline degeneration in partial hyperplastic collagen. We observed vascular dilatation and proliferation within the hyperplastic fibrous connective tissue in the dermis and no infiltration of inflammatory cells (Figure 1). Conclusively, a diagnosis of irritation fibroma was made. No recurrence has occurred after 6 months’ follow-up.
Irritation fibroma is an exophytic soft tissue mass in the oral mucosa. Indeed, it is not a real neoplasm but a focal hyperplasia of fibrous connective tissue induced by local trauma or chronic irritation [1, 2]. An earlier population-based epidemiological analysis showed that irritation fibroma was the second common benign oral lesion in Caucasians over 35 years of age [3]. The predilection sites were the buccal mucosa, labial and lingual surfaces. It also revealed that there was no prominent difference in the incidence rate between the sexes. However, data may vary from country to country regarding the occurrence of oral diseases in subsequent retrospective studies [4, 5].
Clinically, irritation fibromas usually manifest an exophytic, firm and asymptomatic nodule with pink or flesh-colored and smooth surface. The nodule often has a well-defined boundary. It is slow-growing and rarely exceeds 1.5 cm in diameter. The histopathological feature of irritation fibroma appears as a nodular mass composed of collagenized fibrous connective tissue. The epidermis usually presents hyperplasia and hyperkeratosis due to chronic irritation. Dense collagen fibers and focal hyperplasia of mature fibroblasts can be found in connective tissue, with...


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