A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60

Farnaz Amouzegar Hashemi; Sepideh Mansouri; Mahdi Aghili; Ebrahim Esmati; Mohammad Babaei; Arefeh Saeedian; Sepand Moalej; Ramin Jaberi

doi:10.5114/jcb.2021.110312

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

A comparison between 2D and 3D planning of high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60

Farnaz Amouzegar Hashemi

¹

,

Sepideh Mansouri

^{1, 2}

,

Mahdi Aghili

¹

,

Ebrahim Esmati

¹

,

Mohammad Babaei

¹

,

Arefeh Saeedian

^{1, 3}

,

Sepand Moalej

⁴

,

Ramin Jaberi

⁵

Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Department of Radiation Oncology, Imam Khomeini Hospital Complex, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Western University of Health Sciences, Pomona, USA

Physics Department of Radiation Oncology, Tehran University of Medical Sciences, Tehran, Iran

J Contemp Brachytherapy 2021; 13, 5: 526–532

DOI: https://doi.org/10.5114/jcb.2021.110312

Online publish date: 2021/10/25

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AMA

Amouzegar Hashemi F, Mansouri S, Aghili M, et al. A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60. Journal of Contemporary Brachytherapy. 2021;13(5):526-532. doi:10.5114/jcb.2021.110312.

APA

Amouzegar Hashemi, F., Mansouri, S., Aghili, M., Esmati, E., Babaei, M.,  & Saeedian, A. et al. (2021). A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60. Journal of Contemporary Brachytherapy, 13(5), 526-532. https://doi.org/10.5114/jcb.2021.110312

Chicago

Amouzegar Hashemi, Farnaz, Sepideh Mansouri, Mahdi Aghili, Ebrahim Esmati, Mohammad Babaei, Arefeh Saeedian,  and Sepand Moalej et al. 2021. "A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60". Journal of Contemporary Brachytherapy 13 (5): 526-532. doi:10.5114/jcb.2021.110312.

Harvard

Amouzegar Hashemi, F., Mansouri, S., Aghili, M., Esmati, E., Babaei, M., Saeedian, A., Moalej, S.,  and Jaberi, R. (2021). A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60. Journal of Contemporary Brachytherapy, 13(5), pp.526-532. https://doi.org/10.5114/jcb.2021.110312

MLA

Amouzegar Hashemi, Farnaz et al. "A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60." Journal of Contemporary Brachytherapy, vol. 13, no. 5, 2021, pp. 526-532. doi:10.5114/jcb.2021.110312.

Vancouver

Amouzegar Hashemi F, Mansouri S, Aghili M, Esmati E, Babaei M, Saeedian A et al. A comparison between 2D and 3D planning of 
high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60. Journal of Contemporary Brachytherapy. 2021;13(5):526-532. doi:10.5114/jcb.2021.110312.

Introduction
Post-surgery radiation can reduce the risk of loco-regional relapse in high-intermediate-risk endometrial cancer. High-dose-rate vaginal cuff brachytherapy (HDR-BRT) is an acceptable method of radiation in majority of endometrial cancer cases. Although 2D planning is frequently used for treatment based on physical examination without any imaging, measurement of the dose received by organs-at-risk (OARs) is not possible. Therefore, the present study was the first to compare dose delivered to target and OARs in 2D vs. 3D planning in patients treated with cobalt-60 source.

Material and methods
In this study, organs including vagina wall, bladder, rectum, and sigmoid were contoured on computed tomography (CT) scan images of 37 endometrial cancer patients, and doses delivered to organs were recorded. Statistics, such as D90, D99, V100, V150, V200, D0.1cc, D1cc, and D2cc were determined.

Results
D90 and D99 were lower in 3D treatment planning in comparison with 2D. Although V100 was more in 3D planning, V150 and V200 were less. Analyzing D0.1cc, D1cc, and D2cc of OARs revealed that doses given to rectum, sigmoid, and bladder were less in 3D planning compared to 2D.

Conclusions
Comparison of 2D and 3D planning results showed that 3D planning could deliver an appropriate dose to the target while sparing more OARs.

keywords:

A comparison between 2D and 3D planning of high-dose-rate vaginal cuff brachytherapy in patients with stage I-II endometrial cancer using cobalt-60

Farnaz Amouzegar Hashemi 1 , Sepideh Mansouri 1, 2 , Mahdi Aghili 1 , Ebrahim Esmati 1 , Mohammad Babaei 1 , Arefeh Saeedian 1, 3 , Sepand Moalej 4 , Ramin Jaberi 5

dosimetry, high-dose-rate brachytherapy, 2D and 3D planning, endometrial cancer, organs-at-risk

Farnaz Amouzegar Hashemi

¹

,

Sepideh Mansouri

^{1, 2}

,

Mahdi Aghili

¹

,

Ebrahim Esmati

¹

,

Mohammad Babaei

¹

,

Arefeh Saeedian

^{1, 3}

,

Sepand Moalej

⁴

,

Ramin Jaberi

⁵