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2/2025
vol. 100 abstract:
Case report
A rare presentation of giant teratoma in the mediastinum of an adolescent – a case report and treatment outcome
Iwona Anderko
1
,
Patrycja Sosnowska-Sienkiewicz
2
,
Mateusz Szot
1
,
Paulina Haraś
1
,
Przemysław Mańkowski
2
Pediatr Pol 2025; 100 (2): 183-188
Online publish date: 2025/06/09
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Mediastinal teratoma is an unusual germ cell tumor, accounts for 1–5% of all mediastinal tumors and is the most common type of the mediastinal germ cell tumor. While mature mediastinal teratomas are infrequent, their discovery is often incidental. This case presents a 16-year-old boy with left-sided chest pain, dry cough, and decreased exercise tolerance persisting for several weeks. Imaging revealed a large mediastinal mass displacing cardiac structures and compressing the left lung. A biopsy indicated a mixed germ cell tumor, predominantly an immature teratoma with a minor yolk sac tumor component. The patient received four cycles of neoadjuvant chemotherapy, followed by complete surgical resection, with histopathology confirming a benign mature teratoma. Two months post-surgery, he developed myelodysplastic syndrome, likely related to chemotherapy, and underwent an allogeneic stem cell transplant. This case underscores the importance of multidisciplinary care and vigilant follow-up in managing large mediastinal germ cell tumors in adolescents.
keywords:
neoadjuvant chemotherapy, germ cell tumor, mediastinal teratoma, myelodysplastic syndrome |
POLSKI
