eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2018
vol. 35
 
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abstract:
Original paper

A systematic review and meta-analysis study of salivary and serum interleukin-8 levels in oral lichen planus

Hamid Reza Mozaffari, Roohollah Sharifi, Seyedghasem Mirbahari, Sara Montazerian, Masoud Sadeghi, Sedigheh Rostami

Adv Dermatol Allergol 2018; XXXV (6): 599-604
Online publish date: 2018/08/13
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Introduction
Interleukin-8 (IL-8) is an important mediator of the host response to injury and inflammation that the clinical severity of oral lichen planus (OLP) is associated with elevated serum IL-8 levels.

Aim
To evaluate serum and salivary IL-8 levels of the OLP patients compared with the healthy controls and measurement of IL-8 level in which sample is more valuable.

Material and Methods
Five databases including PubMed/Medline, Web of Science, Science Direct, Cochrane Library and Scopus were searched for the evaluation of serum and salivary IL-8 levels of the OLP patients compared with the healthy controls in the English abstract. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used for checking the quality of the studies. A random-effect model was used for calculating the mean difference (MD) and 95% confidence intervals (CIs).

Results
Nine studies were included in the meta-analysis. The pooled estimate showed a significant difference between two groups that the salivary IL-8 level in the OLP patients was higher than the healthy controls (MD = 766.32 pg/ml, 95% CI: 394.90–1137.75; p < 0.0001) and also the serum IL-8 level in the OLP patients was higher than the healthy controls (MD = 8.38 pg/ml, 95% CI: 3.32–13.44; p = 0.001).

Conclusions
The higher levels of IL-8 in saliva compared with serum levels suggest that measurement of this marker in saliva may be more useful than serum measurements for determining therapeutic and diagnostic aims.

keywords:

oral lichen planus, interleukin-8, saliva, serum

references:
Drogoszewska B, Chomik P, Polcyn A, Michcik A. Clinical diagnosis of oral erosive lichen planus by direct oral microscopy. Postep Dermatol Alergol 2014; 31: 222-8.
Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom K. Oral lichen planus: clinical features and management. Oral Dis 2005; 11: 338-49.
Mozaffari HR, Rahmani M, Rezaei F, et al. Evaluation of oral lichen planus frequency in patients referred to pathology centers of Kermanshah city, during 2008 to 2011. Sch J App Med Sci 2016; 4: 2200-2.
Lodi G, Scully C, Carrozzo M, et al. Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100: 40-51.
Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of oral lichen planus in diabetes mellitus: a meta-analysis study. Acta Inform Med 2016; 24: 390-3.
Mozaffari HR, Ramezani M, Mahmoudiahmadabadi M, et al. Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study. Oral Surg Oral Med Oral Pathol Oral Radiol 2017; 124: e183-9.
Rhodus NL, Cheng B, Myers S, et al. The feasibility of monitoring NF-kappaB associated cytokines: TNF-αlpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. Mol Carcinog 2005a; 44: 77-82.
Rhodus NL, Cheng B, Myers S, et al. A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-αlpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol 2005b; 114: 278-83.
Sun A, Wang JT, Chia JS, Chiang CP. Serum interleukin-8 level is a more sensitive marker than serum interleukin-6 level in monitoring the disease activity of oral lichen planus. Br J Dermatol 2005; 152: 1187-92.
Chen F, Castranova V, Shi X. New insights into the role of nuclear factor-kappaB in cell growth regulation. Am J Pathol 2001; 159: 387-97.
al-Dalaan A, al-Sedairy S, al-Balaa S, et al. Enhanced interleukin 8 secretion in circulation of patients with Behcet’s disease. J Rheumatol 1995; 22: 904-7.
Shahriary A, Panahi Y, Shirali S, Rahmani H. Relationship of serum levels of interleukin 6, interleukin 8, and C-reactive protein with forced expiratory volume in first second in patients with mustard lung and chronic obstructive pulmonary diseases: systematic review and meta-analysis. Postep Dermatol Alergol 2017; 34: 192-8.
Wang LM, Kitteringham N, Mineshita S, et al. The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behcet’s disease. Arch Dermatol Res 1997; 289: 444-7.
Rhodus NL, Cheng B, Bowles W, et al. Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. Oral Dis 2006; 12: 112-6.
Yamamoto T, Yoneda K, Ueta E, Osaki T. Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders. Oral Surg Oral Med Oral Pathol 1994; 78: 727-35.
Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2008. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp (accessed 1/03/2016).
Lisa Cheng YS, Jordan L, Gorugantula LM, et al. Salivary interleukin-6 and -8 in patients with oral cancer and patients with chronic oral inflammatory diseases. J Periodontol 2014; 85: 956-65.
Zhu Y, Li J, Bai Y, et al. Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus. Clin Oral Investig 2014; 18: 1903-11.
Tavangar A, Khozeimeh F, Ghoreishian F, Boroujeni MA. Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: a biochemical study. Dent Res J (Isfahan) 2016; 13: 413-8.
Zhang Y, Lin M, Zhang S, et al. NF-kappaB-dependent cytokines in saliva and serum from patients with oral lichen planus: a study in an ethnic Chinese population. Cytokine 2008; 41: 144-9.
Kaur J, Jacobs R. Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis. J Korean Assoc Oral Maxillofac Surg 2015; 41: 171-5.
Mignogna MD, Fedele S, Lo Russo L, et al. Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncol 2004; 40: 120-30.
Alikhani M, Ghalaiani P, Askariyan E, et al. Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. Braz Oral Res 2017; 31: e10.
Kaufman E, Lamster IB. The diagnostic applications of saliva – a review. Crit Rev Oral Biol Med 2002; 13: 197-212.
Lawrence HP. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc 2002; 68: 170-4.
Dan H, Liu W, Zhou Y, et al. Association of interleukin-8 gene polymorphisms and haplotypes with oral lichen planus in a Chinese population. Inflammation 2010; 33: 76-81.
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