We present a case of a 75-year-old female with a subcutaneous back mass diagnosed as myoepithelioma of soft tissue. The diagnosis of this tumor may be challenging and familiarity with its broad morphological spectrum is important to distinguish it from a number of histologically similar soft tissue proliferations, in particular those displaying a prominent myxoid stroma. The correct diagnosis can be facilitated by the use of a panel of confirmatory immunohistochemical markers, including cytokeratins, neural, and muscular antigens, revealing the myoepithelial nature of the tumor cells.