eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
 
4/2022
vol. 60
 
Share:
Share:
more
 
 
abstract:
Case report

Acute disseminated encephalitis in an adult patient addicted to heroin. Neuropathological, neuroradiological and clinical features

Michał Sobstyl
1
,
Anna Rzehak
1
,
Dawid Szczechowski
2
,
Albert Acewicz
3
,
Ewelina Mackiewicz
4
,
Iwona Kurkowska-Jastrzębska
2

1.
Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
2.
Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
3.
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
4.
Department of Neuroradiology, Institute of Psychiatry and Neurology, Warsaw, Poland
Folia Neuropathol 2022; 60 (4): 449-456
Online publish date: 2022/12/30
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
PlumX metrics:
Acute disseminated encephalomyelitis (ADEM) is an immune demyelinating central nervous system (CNS) disorder, characterized by monophasic new onset neurological symptoms including encephalopathy, combined with neuroradiological evidence of multifocal demyelination. ADEM is extremely rarely diagnosed and is much more common in children and adolescents than in adults. The aim of this study is to present an extremely rare case of ADEM in a heroin-addicted patient with a very difficult diagnostic course. The results of the magnetic resonance imaging (MRI) examination in this patient were inconclusive. Fungal abscesses or inflammatory lesions of an unclear nature were suspected especially in a patient with impaired immunodeficiency. In view of the constantly deteriorating condition of the patient with disturbed consciousness and the unclear aetiology, the lack of effective treatment, a decision was made to perform a bilateral stereotactic biopsy and aspiration of brain abnormalities in order to obtain a neuropathological specimen and begin with the causal treatment. Neuropathological examination revealed the presence of Creutzfeldt-Peters cells characteristic of ADEM. Treatment with methylprednisolone significantly improved the patient’s general and neurological condition.

To our knowledge, the above case is the first in the world literature in which ADEM has been confirmed by bilateral stereotaxic aspiration for the treatment of symptoms of increased intracranial pressure as a lifesaving procedure. Neuropathological confirmation allowed for the implementation of appropriate treatment, which resulted in complete recovery. Moreover, this case is interesting because ADEM was diagnosed in a patient addicted to heroin, where opportunistic inflammation of a fungal aetiology was considered in the first place.
keywords:

acute disseminated encephalomyelitis, stereotactic biopsy, Creutzfeldt-Peters cells, increased intracranial pressure

Quick links
© 2023 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.