Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare hereditary syndrome worldwide due to certain gene mutations and histological appearances that affect the peripheral pathway of noxious stimuli transmission and the innervation of sweat glands. It is characterized by insensitivity to pain, anhidrosis, and heat intolerance. We describe the clinical features and the anaesthetic management of a 24-year old Greek man suffering from CIPA, who uneventfully underwent an internal osteosynthesis of the femoral bone under general anaesthesia. This is also the first reported case with congenital insensitivity to pain and anhidrosis in Greece