eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2016
vol. 54
 
Share:
Share:
abstract:
Original paper

Analysis of Olig2 and YKL-40 expression: a clinicopathological/immunohistochemical study for the distinction between subventricular zone II and III glioblastomas

Kelvin Manuel Piña Batista
,
Bruno Augusto Lourenco Costa
,
Isabel Cuervo-Arango Herreros
,
Ivan Fernandez Vega
,
Julio Cesar Gutierrez Morales
,
Aitana Vallina Alvarez
,
Pablo Isidro Marron
,
Ángela Meilán
,
Aurora Astudillo
,
Kenia Yoelvi Alvarez

Folia Neuropathol 2016; 54 (1): 31-39
Online publish date: 2016/03/31
View full text Get citation
 
PlumX metrics:
Glioblastomas (GBs) are the most common and lethal primary brain tumors in the adults. Glioblastomas originates either from astrocytes that have accumulated mutations and de-differentiated or from neural stem cells within the subventricular zone (SVZ) in close contact with the vasculature. Recently, several studies have hypothesized that gliomagenesis occurs in perivascular niches with highly invasive peripheral proliferating zones. The purpose of our study was to investigate the pathological and clinical significance of Olig2 and YKL40 immunoexpression in 152 GBs in relationship to the SVZ II and III. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II GBs and 16 (21.3%) of 75 SVZ type III GBs, respectively. YKL-40 expression was observed in 45 (58.4%) of 77 SVZ type II GBs and in 17 (22.6%) of 75 SVZ type III GBs, respectively. Stepwise multivariate Cox proportional hazards models were used, and the prognostic factors to significantly impact OS were: PFS < 54 weeks (HR: 5.86; CI: 3.02-11.33; p = 0.00); radiotherapy (HR: 0.34; CI: 0.18-0.60; p = 0.00); radio- and chemotherapy (HR: 0.05; CI: 0.03-0.10; p = 0.0), and YKL-40+ GBs (HR: 1.61; CI: 1.28-2.31; p = 0.01).
keywords:

glioblastoma, subventricular zone, Olig2, YKL-40, clinicopathological, immunohistochemical

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.