Angiogenesis of ovarian neoplasms

Objective: The aim of this study was to evaluate the importance of angiogenesis intensity in the diagnostics and differentiation of ovarian neoplasmatic tumors.
Material and methods: The study group consisted of 42 women with ovarian cancer, and 10 patients with ovarian tumors of borderline malignancy as a control group. The paraffin tumor sections were immunohistochemically stained with Dako monoclonal antibodies, and then angigenesis was assessed in the light microscope at 400x oil immersion magnification.
Results: The IMD in ovarian cancers in one high-power microscopic field was 23.9±12.0 and in borderline tumors it was 12.3±2.6 (p<0.001). The IMD in patients with ovarian cancer aged 29–45 was 25.8±14.9, in women aged 46–55 years it was 23.5±12.7 and in women aged 56–84 it was 22.6±10.0. The IMD in FIGO stages I and II was 20.6±12.3 and in stages III and IV it was 25.1±12.0. When tumor size was under 10 cm, the IMD was 18.8±7.5, in the case of tumor size exceending 10 cm it was 27.4±14.6. In cases of the disseminated neoplasmatic disease, the IMD was 22.8±11.1. The IMD was 22.2±17.0 in G1 cancers, 31.5±14.1 in G2 tumors, and 21.2±9.8 in G3 neoplasms. In serous cancers the IMD was 24.9 (9.9, in mucinous it was 21.1±13.5, in endometrioid ones it was 29.1±15.7, in solid ones it was 16.4±3.5, and in another cancers it was 20.4±9.3. All these differences were statistically insignificant. Conclusions: The level of angiogenesis in malignant neoplasms is significantly higher when compared to borderline tumors, and does not dependend on clinical staging and histological grading. We did not found any correlation between the intensity of angiogenesis and the histological type of ovarian cancers.