eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2023
vol. 74
 
Share:
Share:
abstract:
Original paper

Angiotensin-converting enzyme insertion/deletion gene polymorphism and Henoch-Schonlein purpura nephritis risk in children: a meta-analysis

Pan Yan
1
,
Song Xu
1

1.
Department of Paediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China
Pol J Pathol 2023; 74 (1): 29-35
Online publish date: 2023/04/27
View full text Get citation
 
PlumX metrics:
It has been demonstrated in many studies that angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is related to Henoch-Schonlein purpura nephritis (HSPN) risk in children. However, this conclusion remains controversial.

In this study, we systemically retrieved relevant studies in electronic databases such as PUBMED, CNKI, and EMBASE followed by calculation of odds ratios (OR) with 95% confidence intervals (CI). In addition, meta-package in STATA version 12.0 was used. Angiotensin-converting enzyme I/D polymorphism was related to HSPN susceptibility in children (D vs. I: OR 1.47, 95% CI: 1.13–1.93; DD vs. II: OR 2.29, 95% CI: 1.29–4.07; DI vs. II: OR 1.10, 95% CI: 0.82–1.48; dominant model: OR 1.44, 95% CI: 1.09–1.89; recessive model: OR 2.26, 95% CI: 1.67–3.06).

In addition, subgroup analysis stratified according to ethnicity indicated a significant relationship between this polymorphism and HSPN susceptibility among Asians and Caucasians. The data extracted from HaploReg indicated that ACE I/D polymorphism was not in linkage disequilibrium with other variants in the ACE gene.

The research shows that ACE I/D polymorphism is related to HSPN susceptibility in children.
keywords:

ACE, HSPN, meta-analysis

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.