eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2003
vol. 28
 
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abstract:

Anti-inflammatory drugs in asthma therapy

Andrzej Obojski
,
Maria Kraus-Filarska

(Centr Eur J Immunol 2003; 28 (1): 29–35)
Online publish date: 2004/01/20
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Abstract
Asthma is a chronic inflammatory disease. Pharmacologic management of asthma comprises long-term treatment to suppress the airway inflammation and quick-relief treatment to provide prompt reversal of acute bronchoconstriction and its accompanying symptoms. Anti-inflammatory agents are of crucial importance in asthma therapy. The most potent and effective medications used for long-term treatment of asthma are inhaled corticosteroids. Other medications, like: cromones, leukotriene antagonists and theophylline also show, but much less, anti-inflammatory activity. They can be used alternatively to inhaled corticosteroids in patients with mild persistent asthma but they are less effective. The add-on therapy with those medications should be considered if asthma control is not achieved with initial inhaled corticosteroid therapy. The combination treatment with long-acting β2-agonists and inhaled corticosteroids has become the treatment of choice for the majority of asthmatic patients and nowadays constitutes the new ”gold standard” of asthma therapy.
keywords:

anti-inflammatory agents, inhaled corticosteroids, leukotriene antagonists, long-acting β2-agonists, theophylline, cromones

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