Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease

Silvia García; Luz López-Hernández; Luis Dávila-Maldonado; Carlos Cuevas-García; Martha Gallegos-Arreola; Sofía Alcaraz-Estrada; Leticia Cortes-Espinosa; Carlos Flores; Patricia Canto; Ramón Vázquez

doi:10.5114/fn.2019.89859

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Original paper

Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease

Silvia García

¹

,

Luz Berenice López-Hernández

¹

,

Luis Dávila-Maldonado

²

,

Carlos Cuevas-García

³

,

Martha Patricia Gallegos-Arreola

⁴

,

Sofía Lizeth Alcaraz-Estrada

¹

,

Leticia Cortes-Espinosa

¹

,

Carlos Palma Flores

^{5, 6}

,

Patricia Canto

⁷

,

Ramón Mauricio Coral Vázquez

^{6, 8}

Centro Médico Nacional “20 de Noviembre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México

Instituto de Ciencias Médicas y de la Nutrición Salvador Zubirán, Ciudad de México, Mexico

Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico

Centro de Investigación Biomédica de Occidente, Jalisco, Mexico

Catedrático CONACYT, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México

Subdirección de Enseñanza e Investigación, Centro Médico Nacional “20 de Noviembre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México

Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México

Folia Neuropathol 2019; 57 (4): 335-339

DOI: https://doi.org/10.5114/fn.2019.89859

Online publish date: 2019/11/18

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AMA

García S, López-Hernández LB, Dávila-Maldonado L, et al. Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease. Folia Neuropathologica. 2019;57(4):335-339. doi:10.5114/fn.2019.89859.

APA

García, S., López-Hernández, L. B., Dávila-Maldonado, L., Cuevas-García, C., Gallegos-Arreola, M. P.,  & Alcaraz-Estrada, S. L. et al. (2019). Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease. Folia Neuropathologica, 57(4), 335-339. https://doi.org/10.5114/fn.2019.89859

Chicago

García, Silvia, Luz B López-Hernández, Luis Dávila-Maldonado, Carlos Cuevas-García, Martha P Gallegos-Arreola, Sofía L Alcaraz-Estrada,  and Leticia Cortes-Espinosa et al. 2019. "Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease". Folia Neuropathologica 57 (4): 335-339. doi:10.5114/fn.2019.89859.

Harvard

García, S., López-Hernández, L., Dávila-Maldonado, L., Cuevas-García, C., Gallegos-Arreola, M., Alcaraz-Estrada, S., Cortes-Espinosa, L., Flores, C., Canto, P.,  and Vázquez, R. (2019). Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease. Folia Neuropathologica, 57(4), pp.335-339. https://doi.org/10.5114/fn.2019.89859

MLA

García, Silvia et al. "Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease." Folia Neuropathologica, vol. 57, no. 4, 2019, pp. 335-339. doi:10.5114/fn.2019.89859.

Vancouver

García S, López-Hernández L, Dávila-Maldonado L, Cuevas-García C, Gallegos-Arreola M, Alcaraz-Estrada S et al. Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease. Folia Neuropathologica. 2019;57(4):335-339. doi:10.5114/fn.2019.89859.

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Introduction
Sporadic Parkinson’s disease (PD) is a neurodegenerative disorder of unknown etiology. In recent years, it has been established that a genetic component underlies different forms of the disease. For instance, mitochondrial genome variants have been implicated in the pathogenesis of the PD.

Aim of the study
To determine the association of tRNA(Gln) 4336 and 8701A>G (ATP6: Thr59Ala) mitochondrial DNA polymorphisms with the presence of PD in Mexican mestizo patients.

Material and methods
This was a cross-sectional study in which patients were recruited from four tertiary-care level hospitals in Mexico. Genotyping was performed using real-time PCR with TaqMan genotyping assays. Genotypes were confirmed by automated sequencing.

Results
The 4336C allele of the tRNAGln gene was present at a low frequency, and the 8701G allele of the MT-ATP6 gene was not associated with PD.

Conclusions
The 4336C variant of the tRNAGln gene was uncommon in the study population, and 8701A/G of MT-ATP6 was not associated with PD in Mexican Mestizos.

keywords:

Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease

Silvia García 1 , Luz Berenice López-Hernández 1 , Luis Dávila-Maldonado 2 , Carlos Cuevas-García 3 , Martha Patricia Gallegos-Arreola 4 , Sofía Lizeth Alcaraz-Estrada 1 , Leticia Cortes-Espinosa 1 , Carlos Palma Flores 5, 6 , Patricia Canto 7 , Ramón Mauricio Coral Vázquez 6, 8

Parkinson’s disease, association, variants tRNAGln, MT-ATP6, genes