eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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SCImago Journal & Country Rank
4/2019
vol. 57
 
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abstract:
Original paper

Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease

Silvia García
,
Luz Berenice López-Hernández
,
Luis Dávila-Maldonado
,
Carlos Cuevas-García
,
Martha Patricia Gallegos-Arreola
,
Sofía Lizeth Alcaraz-Estrada
,
Leticia Cortes-Espinosa
,
Carlos Palma Flores
,
Patricia Canto
,
Ramón Mauricio Coral Vázquez

Folia Neuropathol 2019; 57 (4): 335-339
Online publish date: 2019/11/18
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Introduction
Sporadic Parkinson’s disease (PD) is a neurodegenerative disorder of unknown etiology. In recent years, it has been established that a genetic component underlies different forms of the disease. For instance, mitochondrial genome variants have been implicated in the pathogenesis of the PD.

Aim of the study
To determine the association of tRNA(Gln) 4336 and 8701A>G (ATP6: Thr59Ala) mitochondrial DNA polymorphisms with the presence of PD in Mexican mestizo patients.

Material and methods
This was a cross-sectional study in which patients were recruited from four tertiary-care level hospitals in Mexico. Genotyping was performed using real-time PCR with TaqMan genotyping assays. Genotypes were confirmed by automated sequencing.

Results
The 4336C allele of the tRNAGln gene was present at a low frequency, and the 8701G allele of the MT-ATP6 gene was not associated with PD.

Conclusions
The 4336C variant of the tRNAGln gene was uncommon in the study population, and 8701A/G of MT-ATP6 was not associated with PD in Mexican Mestizos.

keywords:

Parkinson’s disease, association, variants tRNAGln, MT-ATP6, genes

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