eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2007
vol. 3
 
Share:
Share:
more
 
 
abstract:

Basic research
Vitamin C pre-medication enhances the anaesthetic effect of ketamine-xylazine combination in the rat

Alireza Najafpour
,
Goudarz Sadeghi-Hashjin

Arch Med Sci 2007; 3, 4: 340-343
Online publish date: 2008/01/09
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 

Introduction: This experimental study was designed to study the effects of ascorbic acid (vitamin C = VitC) for premedication on ketamine/xylazine anaesthesia in the rat.
Material and methods: Fifty albino laboratory rats (Sprague-Dawley) of either sex were divided into five groups (A, B, C, D and E) of ten rats in each. Rats in groups C, D and E were pre-treated with 50, 100 and 150 mg/kg, respectively, of VitC. The animals in group A (control) were treated neither with VitC nor ketamine/xylazine. A combination of ketamine 5% (40 mg/kg) and xylazine 2% (5 mg/kg) was administrated intraperitoneally (I.P.) to all groups except group A. The onset and duration of hypnosis as well as vital signs were observed and recorded.
Results: There was a significant (p<0.01) decrease in the onset and increased duration of anaesthesia in the animals treated with medium (group D) and high (group E) doses of VitC. Heart and respiratory rates were decreased in all anaesthetized animals, irrespective of the presence or absence of the pre-treatment and dose of vitamin C.
Conclusions: VitC at 150 mg/kg administration prior to ketamine/xylazine treatment could be used to decrease the time needed to induce and to increase the duration of anaesthesia in rats. Application of VitC as a premedication agent in clinical practice, therefore, might be of interest in human and animal patients to use a lower dose of anaesthetics and, therefore, to minimize their side effects.
keywords:

ascorbic acid, vitamin C, premedication, ketamine, xylazine, rat, general anaesthesia

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe