eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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4/2012
vol. 50
 
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abstract:
Review paper

Belimumab – new treatment opportunities in systemic lupus erythematosus

Magdalena Szmyrka-Kaczmarek
,
Piotr Wiland

Reumatologia 2012; 50, 4: 349–361
Online publish date: 2012/09/07
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Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease which course is characterized by flares and remissions. Despite the progress in its therapy and longer lifespan of patients it still remains a disease of uncertain prognosis and prolonged therapy, including steroid treatment, carries a burden of many side effects. No new treatment have been accepted in SLE for the last 50 years. It has changed lately, as the first biologic treatment – belimumab, monoclonal antibody anty-BLyS – has been registered in SLE. Belimumab inhibits growth factor for B-lymphocytes and in the large clinical trials has proved safe and efficacious in the treatment of SLE. It is especially indicated in patients with active disease, with positive anti-dsDNA antibodies and low complement and dependent on steroids.
keywords:

belimumab, systemic lupus erythematosus





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