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Alergologia Polska - Polish Journal of Allergology
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2/2023
vol. 10
 
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abstract:
Special paper

Biological therapy of severe asthma – Position of Polish Society of Allergology and Polish Society of Respiratory Diseases

Barbara Rogala
1
,
Maciej Kupczyk
2
,
Grażyna Bochenek
3
,
Paweł Śliwiński
4
,
Marcin Moniuszko
5
,
Piotr Kuna
2
,
Joanna Glück
1
,
Rafał Dobek
4
,
Marek Kulus
6
,
Aleksandra Kucharczyk
7
,
Maciej Chałubiński
8

  1. Uniwersyteckie Centrum Kliniczne, Śląski Uniwersytet Medyczny w Katowicach, Polska
  2. Klinika Chorób Wewnętrznych, Astmy i Alergii, Uniwersytet Medyczny w Łodzi, Polska
  3. II Katedra Chorób Wewnętrznych, Uniwersytet Jagielloński Collegium Medicum w Krakowie, Polska
  4. Klinika Chorób Płuc, Instytut Gruźlicy i Chorób Płuc w Warszawie, Polska
  5. Klinika Alergologii i Chorób Wewnętrznych, Uniwersytet Medyczny w Białymstoku, Polska
  6. Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Warszawski Uniwersytet Medyczny, Polska
  7. Klinika Chorób Wewnętrznych, Pneumonologii i Alergologii, Wojskowy Instytut Medyczny we Warszawie, Polska
  8. Klinka Immunologii i Alergii, Uniwersytet Medyczny w Łodzi, Polska
Alergologia Polska – Polish Journal of Allergology 2023; 10, 2: 77–99
DOI: https://doi.org/10.5114/pja.2023.129093
Online publish date: 2023/06/30
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Biological therapy represents a breakthrough advance in the treatment of many diseases, including asthma. This article presents the state of knowledge concerning the immunopathophysiology of asthma justifying the use of biological drugs, the essence of whose mechanism is a suppressive effect on biologically active proteins determining the phenotypic manifestation of the disease. Data demonstrating the safety and efficacy of biological therapy and the prospects for further development of this area of medicine are presented.
keywords:

severe asthma, immunopathophysiology, biological therapy, efficacy, safety



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